López-Domínguez A, Pasantes H

Language: Spanish
References: 18
Page: 132-140
PDF size: 398.66 Kb.

ABSTRACT

Brain water is distributed between blood, cerebrospinal fluid, interstitial and intracellular compartments and moves across these compartments following differences in osmotic and hydrostatic pressures.Brain edema occurs bywater accumulation resulting fromblood brain barrier disruption (vasogenic edema) or by increase in cellwater resulting either from a hyponatremic condition or by osmolyte redistribution between the extracellular and intracellular compartments (cytotoxic edema). In most pathologies, one type of edema gradually results in the development of the other type. The role of aquaporins in the generation or/and the control of brain edema is nowextensively investigated.This reviewinforms about recent result on this topic.

REFERENCES

1. Carbrey JM,Agre P (2009) Discovery of the aquaporins and development of the field. Handb Exp Pharmacol 190:3-28.

2. Verkman AS (2005)More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci 118: 3225-3232.

3. TaitMJ, Saadoun S, Bell BA, PapadopoulosMC (2008) Watermovements in the brain: role of aquaporins. Trends Neurosci 31:37-43.

4. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS (1994)Molecular cloning of amercurial-insensitive water channel expressed in selected water-transporting tissues. Biol Chem 269:5497-5500.

5. Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC (2006) Three distinct roles of aquaporin-4 in brain function revealed by knockoutmice. Biochim Biophys Acta 1758:1085-1093.

6. Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (1994) Molecular characterization of an aquaporin cDNAfrombrain: candidate osmoreceptor and regulator ofwater balance. Proc NatlAcad Sci 91:13052- 13056.

7. PapadopoulosMC,VerkmanAS (2007)Aquaporin-4 and brain edema. Pediatr Nephrol 22:778-784.

8. PapadopoulosMC,Manley GT, Krishna S, VerkmanAS (2004) Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18:1291-1293.

9. Hoffmann EK, Lambert IH, Pedersen SF. (2009) Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193-277.

10. Pasantes-Morales H, Franco R (2005) Astrocyte cellular swelling: mechanisms and relevance to brain edema. En: The Role of Glia in Neurotoxicity. Editores:Aschner M, Costa L. CRC-Press, pp.173-190.

11. Solenov E, Watanabe H, Manley GT, Verkman AS (2004) Sevenfold-reduced osmotic water permeability in primary astrocyte cultures fromAQP-4-deficientmice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol 286:C426-C432.

12. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-163.

13. Zador Z, Bloch O, Yao X, Manley GT (2007) Aquaporins: role in cerebral edema and brain water balance. Prog Brain Res 161:185-194.

14. Hsu MS, Lee DJ, Binder DK (2007) Potential role of the glial water channel aquaporin-4 in epilepsy. Neuron Glia Biol 3:287-297.

15. Morishima T, Aoyama M, Iida Y, Yamamoto N, Hirate H, Arima H, Fujita Y, Sasano H, Tsuda T, Katsuya H, Asai K, Sobue K (2008) Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes. Neurosci Res 61:18-26.

16. Manley GT, Binder DK, Papadopoulos MC, Verkman AS (2004) New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience 129: 983-991.

17. Sun MC, Honey CR, Berk C,Wong NL, Tsui JK (2003) Regulation of aquaporin-4 in a traumatic brain injury model in rats. J Neurosurg 98:565-569.

18. Rama Rao KV, Norenberg MD (2007) Aquaporin-4 in hepatic encephalopathy. Metab Brain Dis 22:265-275.