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2010, Number 6

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Rev Med Inst Mex Seguro Soc 2010; 48 (6)

Prenatal dexametasone and periventricular leucomalacia in prematures

Veloz-Serrano CV, Hernández-Herrera RJ, García-Quintanilla F

Language: Spanish
References: 21
Page: 635-638
PDF size: 30.67 Kb.


ABSTRACT

Background: prematurity is observed in 5-8 % of deliveries, and is frequent cause of handicap. Premature have 5-24 % risk for developing periventricular leukomalacia (PLM). The use of antenatal steroids (AS) is controversial for preventing PLM.
Methods: we studied 110 premature neonates < 1500 g, divided in 2 groups: control (group 1, n = 55), and group 2 (n = 55) who received antenatal dexamethasone. We registered clinical data, evolution and use of oxygen or mechanical ventilation. At one month age a transfontanelar ultrasound was done looking specific PLM.
Results: in group 1, found 6/55 (10.9 %) with PLM and 3/55 (5.4 %) in group 2, RR = 0.5, CI 95 % (0.13-1.90). In group 1: 30/55 (54.54 %) the ultrasound was normal; in 16 (29 %) had intraventricular haemorrhage, and in 3 cases (5.45 %) had severe hydrocephalus. In group 2: 32/55 (58.18 %) ultrasound was normal, 16/55 (29 %) had intraventricular haemorrhage, 4/55 (7.27 %) had severe hydrocephalus. We did not find significant difference between other variables in both groups.
Conclusions: there was no significant difference in PLM incidence between patients who did or did not received antenatal dexamethasone.


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