2012, Number 3
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ABSTRACTThe patients suffering stage IIIA non-small cell lung cancer with N2 ganglionic diseases are common and considered as an heterogeneous group by many physicians. Their treatment arouses controversies. For the purpose of making an updated literature review on this topic and defining the treatment options for these patients on this stage III, a number of full articles and of abstracts was searched on several database (Medline, Cochrane, Pubmed, Ebsco, Hinari). To this end, the End Note locator was used with the following English words and their respective Spanish translations: lung cancer, stage IIIa, radiotherapy, chemotherapy, adjuvant treatment, surgery, lymphoadenectomy. The optimal management of patients classified as stage IIIA (N2) remains one of the most controversial areas in the care of patients who suffered non-small cell lung cancer, probably due to the wide pathological variations occurring in this stage. Therefore, it is accepted to apply surgical treatment as first option in those patients presenting with minimal N2 disease, and on the other hand, the definite treatment with chemoradiotherapy or presurgical induction treatment in selected cases.
Friedel G, Budach W, Dippon J. Phase II trial of a trimodality regimen for stage III non-small-cell lung cancer using chemotherapy as induction treatment with concurrent hyperfractionated chemoradiation with carboplatin and paclitaxel followed by subsequent resection: a single-center study. J Clin Oncol. 2010;28(6):942-8.
Esteban E, De Sande JL, Villanueva N, Corral N. Cisplatin plus gemcitabine with or without vinorelbine as induction chemotherapy prior to radical loco regional treatment for patients with stage III non-small-cell lung cancer (NSCLC): results of a prospective randomized study. Lung Cancer. 2007;55(2):173-80.
Inoue M, Sawabata N, Takeda S, Ohta M, Ohno Y, Maeda H. Results of surgical intervention for p-stage IIIA (N2) non- small cell lung cancer: acceptable prognosis predicted by complete resection in patients with single N2 disease with primary tumor in the upper lobe. J Thorac Cardiovasc Surg. 2004;127:1100-6.