2007, Number 1
Rev Educ Bioquimica 2007; 26 (1)
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ABSTRACTThe transcription factor Nrf2 regulates the inducible expression of numerous detoxifying and antioxidant genes. It binds to a specific DNA sequence known as ARE (Antioxidant Response Element), that can be activated by several electrophils and oxidant compounds of diverse chemical nature. Nrf2 activation is constitutively repressed by its binding with a citosolic protein known as Keap1 and to the citoskeleton. This interaction promotes the permanent Nrf2 degradation by the proteosome, implying that the primary control of Nrf2 function lies on its subcellular distribution rather on its de novo synthesis. It has been suggested that the Nrf2- Keap1 system contributes to protection against various pathologies, like cancer, liver toxicity and inflammation.