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2012, Number 4

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Rev Cubana Farm 2012; 46 (4)

Long-term stability of aRhizophora mangle L. (red mangrove) gel for wounds and burns

Soler RDM, Rodríguez PY, Pérez BT, Riverón AY, Morales LIG

Language: Spanish
References: 36
Page:
PDF size: 185.29 Kb.


ABSTRACT

Objective: to evaluate the long-term stability of a gel obtained from the aqueous extract of the Rhizophora mangle L. (red mangrove) bark.
Methods: the three gel pilot batches (GM01, GM02 and GM03) were stored under refrigeration (5 ± 3 °C) for 12 months. Physical-chemical and microbiological evaluations were made at the beginning and after 3, 6, 9 and 12 months.
Results: All these batches kept their appearance of homogeneous, viscous, lump-free and bright gels with dark reddish-brown color and wide areas of extensibility. The pH ranged 6 to 7 and the rheology reflected a non-Newtonian Herschel Bulkley-type fluid with modified potential at all evaluated times. The three batches met the established microbial limit and the minimum inhibitory concentration (MIC) of 8 to 10 mg / mL and the tannin concentration of 13 to 30 mg/g.
Conclusions: it was demonstrated that all the gel batches were stable during the long-term stability study, so it was suggested that the gel should be stored at 2-8 °C for one year.


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