Oscar ZJ, Pelayes D, Singh AD

Language: English
References: 7
Page: 179-181
PDF size: 163.88 Kb.

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The concept of “optical digital biopsy” comprises of two essential components: firstly to capture a high resolution in vivo digital image and then secondly, to unmask the digital image by post processing means so as to achieve tissue and cell identification. Because of optical clarity and anatomic location, both anterior segment and the posterior segment structures of the eye lend itself to imaging. Particularly retina and retinal pigment epithelium (RPE) are amenable to assessment by optical coherence tomography (OCT), a widely used non-invasive technique for high resolution and cross-sectional tomographic imaging.¹,² With rapid improvements in technology and shift to Fourier-domain (FD) OCT, it is possible to capture retinal images 40 to 50 times faster and with higher resolution (axial resolution of less than 6 microns) than standard time domain (TD) OCT.

REFERENCES

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2. Fercher AF, Hitzenberger CK, Drexler W, et al. In vivo optical coherence tomography. Am J Ophthalmol 1993;116:113-4.

3. Wojtkowski M, Bajraszewski T, Gorczynska I, et al. Ophthalmic imaging by spectral optical coherence tomography. Am J Ophthalmol 2004;138:412-9.

4. Hogan H. Diodo Lasers look for that healthy glow. Biophotonics pp. 18-19. May 2002.

5. Stanga P E,Bird A C. Optical Coherence Tomography (OCT):principles of operation,technology,indications in vitreoretinal imaging and interpretation of results.International Ophthalmology 2001;23:191-197. Kluwer Academic Publishers. Netherlands.

6. Brancato R, Lumbroso B.2003.Gide to Optical Coherence Tomography Interpretation. Rome. Innovation. New-Comunication.

7. Bressler NM, Iqbal Ike K. Ahmed.Essential OCT. The Stratus OCT Primer. 2006. Carl Zeiss Meditec.