2012, Number 3
Ondansetron versus lidocaine for the prevention of pain associated with the administration of propofol during induction
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ABSTRACTIntroduction: Pain with the intravenous administration of propofol is a frequent complication during induction in awake patients with an incidence that varies between 28 and 90%. Despite multiple strategies it has not been possible to diminish this frequency. Ondansetron is an antiemetic that may have analgesic properties through 5HT3 receptors. Objective: To evaluate the efficacy of ondansetron pretreatment in diminishing pain with the intravenous administration of propofol during anesthetic induction. Materials and methods: A prospective, randomized, double blind study was performed. 34 patients scheduled for elective surgery under general anesthesia in the operating rooms of the ABC Medical Center were included. Before intravenous administration of propofol, patients were randomly assigned in one of two groups: patients in group (L) received 2 ml of lidocaine and patients in group (O) received 2 ml of ondansetron. Pain was then graded with the use of a four grade Visual Analog Scale. Results were analyzed with SPSS version 15.0 statistics software. Results: 17 patients were included in each of the 2 groups. There were no significant differences in demographics, comorbidities and physical ASA status between both groups. The comparison of pain incidence using the Visual Analog Scale showed in group (L) 3 patients a with score of 0 (18%), 6 patients with 1 (35%), 7 patients with 2 (41%) and 1 patient with 3 (6%). In group (O) there were 3 patients with a score of 0 (18%), 7 patients with 1 (41%), 4 patients with 2 (23%) and 3 patients with 3 (18%). There were no significant differences between both groups. Conclusion: The use of ondansetron before intravenous administration of propofol during induction is as efficient as lidocaine in diminishing pain with the injection of this drug.
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