2011, Number 2
Rev Med MD 2011; 2.3 (2)
Toxoplasma encephalitis masqueraded by chemotherapy for nonhodgkin lymphoma in a VIH infected patient
Álvarez-Villanueva M, Ontiveros-Mercado H
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ABSTRACT43 year old male, diagnosed with Acquired Immune Deficiency Syndrome and diffuselarge B-cell non-Hodgkin lymphoma affecting lungs and Central Nervous System, (CNS) goes through three chemotherapy cycles and intrathecalcytarabine showing partial recovery. Two weeks forward to treatment shows frank central nervous system deterioration. Cranial Magnetic Resonance Imaging (MRI) is performed, which depicts cerebellum and peduncle lesions. Stereotactic biopsy reports proliferative lesions compatible with Non – Hodgkin Lymphoma and the presence of Toxoplasma gondii. NHL occurs in 3 - 4% of HIV infected patients, mainly the B – cell line and it mostly affects liver, gastro intestinal system and central nervous system. Toxoplasma encephalitis comes the majority of times as a result of a reactivation of a latent infection by the HIV virus and a CD4+ lymphocyte level < 200 cels/µ L and is the main cause of focal brain lesions in patients with AIDS.