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2011, Number 6

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Rev Med Inst Mex Seguro Soc 2011; 49 (6)

Recombinant human TSH in pediatric thyroid cancer

Bahena-García A, Saldívar C, Siller P, Lorcansky S, Pitoia F, Tamez-Pérez HE
Full text How to cite this article

Language: Spanish
References: 8
Page: 665-667
PDF size: 29.10 Kb.


Key words:

Thyroid nodule, thyrotropin recombinant, proteins, thyroid neoplasms.

ABSTRACT

The treatment of pediatric thyroid cancer usually includes thyroid surgery, therapeutic radioactive iodine ablation and TSH suppression with levotiroxine. Thyroid hormone withdrawal in the usual follow-up of thyroid cancer has adverse effects on patients. Rh TSH has the advantage of avoiding both hypothyroidism, with a major impact on the patient’s quality of life, and the side effects on tumor growth related to the long-lasting TSH increase. Rh TSH has proven to be effective and safe, but the majority of publications are based on adult population. In this report we present our experience with the administration of rh TSH in the diagnostic evaluation for treatment in a series of four cases of thyroid cancer in children. In all cases we observed clinical benefits without secondary effects. In conclusion rh TSH is an appropriate treatment option for the disease and represents a valuable alternative to thyroxin withdrawal.


REFERENCES

  1. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer; Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19(11):1167-1214.

  2. Tamez-Pérez HE, Saavedra-Castillo E, Oliveros- Rodríguez A, Gómez-de Ossio MD, Hernández-Coria MI, Tamez-Peña AL, et al. Cancer de tiroides en niños y adolescentes. Rev Invest Clin 2004;56(4):449-453.

  3. Hartl DM, Travagli JP. The updated American Thyroid Association guidelines for management of thyroid nodules and differentiated thyroid cancer: a surgical perspective. Thyroid 2009;19(11):1149-1151.

  4. Luster M, Handkiewicz-Junak D, Grossi A, Zacharin M, Taïeb D, Cruz O, et al. Recombinat thyrotropin use in children and adolescents with differentiated thyroid cancer: a multicenter retrospective study. J Clin Endocrinol Metab 2009;94(10):3948-3953. Disponible en http://jcem. endojournals.org/content/94/10/3948.full.pdf+html

  5. Pitoia F. Uso de TSH recombinante humana en el seguimiento del carcinoma diferenciado de tiroides. Glándulas Tiroides y Paratiroides 2002;3(8):4-5.

  6. Khara L, Silverman A, Bethel C, D‘cruz C, Sun X. Thyroid papillary carcinoma in a 3-year-old American boy with a family of thyroid cancer: a case report and literature review. J Pediatr Hematol Oncol 2010;32(3):e118-e121.

  7. O‘Gorman CS, Hamilton J, Rachmiel M, Gupta A, Ngan BY, Daneman D. Thyroid cancer in childhood: a retrospective review of childhood course. Thyroid 2010;20(4): 375-380.

  8. Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management. Curr Opin Oncol 2008;20(1):59-65.




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Rev Med Inst Mex Seguro Soc. 2011;49