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2004, Number 1

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Rev Endocrinol Nutr 2004; 12 (1)

Primary dyslipidemias are frequents in patients with type 2 diabetes following an acute coronary event

Aguilar-Salinas CA, Tamez-Dávila R, Mehta R, Gómez-Pérez FJ

Language: Spanish
References: 13
Page: 42-45
PDF size: 67.89 Kb.


ABSTRACT

Objective: Our objective is to describe the prevalence of primary dyslipidemias in a set of consecutive patients with type 2 diabetes following an acute coronary event in a tertiary care hospital. Data were collected prospectively over a period of 10 months (n = 70). Methods: The assessment included the lipid profiles of at least three first-degree relatives and a search for secondary causes of dyslipidemia. All samples were obtained at least 6 weeks after patients were discharged. FCHL was diagnosed if there was a family history of premature coronary heart disease and hypertriglyceridemia (> 200 mg/dL) and/or hypercholesterolemia (> 200 mg/dL) in at least two different family members. Familial hypertriglyceridemia was diagnosed if hypertriglyceridemia was the only abnormality found among the first-degree relatives. The cases were 37 men and 33 women, aged 62.5 ± 10 years with a body mass index of 26.4 ± 3.2 kg/m2. Results: No lipid abnormality was found either in the proband or in the relatives in 16 cases (22.8%). In 21 cases no lipid abnormalities were found among the first-degree relatives, however, the proband was hyperlipidemic; in all these cases a secondary cause of dyslipidemia was found. Lipid abnormalities were found in both the proband and the relatives in 33 cases (47%). FCHL was the most common primary dyslipidemia; it was diagnosed in 20 cases (28.6%). Other primary dyslipidemias included: FTHG (10 cases (14.3%)), familial hypoalphalipoproteinemia (2 cases (2.8%)) and poligenic hypercholesterolemia (1 case (1.4%)). Conclusion: Our data show that primary dyslipidemias (especially FCHL) are common in patients with type 2 diabetes following and acute


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