González-Hernández LA, Andrade-Villanueva JF, Jave-Suárez LF, Bravo-Cuellar A

Language: Spanish
References: 18
Page: 223-227
PDF size: 572.25 Kb.

ABSTRACT

The Th -17 cells are a subset o f T helper lymphocytes in charge of eliminating pathogens, mainly fungi and mycobacterium not eliminated after the Th-1 and Th-2 cellular response. An important cytokine for the growth of Th-17, is the Transforming Growth Factor beta (TGF-β) sharing the production pathway with the regulatory T cells (Treg). Therefore, by having proinflammatory cytokines, the Th-17 cells are produced; while, in their absence, Treg cells are created. The Th-17 has a tropism through the small intestine and the lymph tissue related to it. They are essential to maintain the integrity of the gastrointestinal mucosa; however, the constant presence of IL-23 would allow an continuous production of Th-17 causing them to acquire a pathologic phenotype and playing a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, inflammatory bowel disease, among others. A better knowledge of the signaling pathways and the TH-17 cell production pathways may lead to therapeutic targets for the treatment of pathologies where the TH-17 cells and/or their cytokines are involved.

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