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2011, Number 3

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Rev Med MD 2011; 2.3 (3)

Immunopathogenesis of Systemic Lupus Erythematosus

Soto-Vargas J

Language: Spanish
References: 38
Page: 170-179
PDF size: 564.84 Kb.


ABSTRACT

Systemic lupus erythematosus (SLE) is an autoimmune disease with many immunological, clinical and laboratory abnormalities. SLE has a genetic component, however it is generally accepted that environmental factors play a key role in the onset and progression of this disease. The principal immunological abnormality is the intolerance to nuclear antibodies. Studies in knock-out models or transgenic animals have provided a conceptual base for understanding the way the organism loses immunologic tolerance to this antibodies. In general, these abnormalities are classified in three categories: 1) defects that promote auto-antigen presentation and the response to apoptotic cells 2) defects that affect the signaling of B and/or T cells causing and abnormal self-reactive stimulation of the lymphocytes and 3) defects that promote the survival of auto-reactive lymphocytes.


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