Barzallo VJF, Pulido GM, Sanabria DJA, León DG, Andrade MR, Mercadillo PP

Language: Spanish
References: 9
Page: 192-195
PDF size: 98.96 Kb.

ABSTRACT

Pemphigus vegetans, rare variant of pemphigus vulgaris, accounting for 5% of all patients with pemphigus disorders. It is divided into the Neumann and Hallopeau types. The Neumann type is characterized by flaccid blisters, that become eroded and form vegetating lesions or papillomatous proliferations, located primarily on flexures. Pemphigus vegetans-Hallopeau type begins with pustules, it is less severe and it responds well to therapy. We describe a case of pemphigus vegetans-Hallopeau type, a 64 years old female, with a dermatosis on the oral mucous, submamary, inguino-crural, perianal and vulvar areas. It consisted of erosions, vegetant masses, flaccid blisters and pustules. The results of histology and direct immunofluorescence studies confirmed the diagnosis. The patient was started on therapy with 1 mg/kg/d of oral prednisone that resulted in complete clinical remission.

REFERENCES

1. Nelson C, Apisarnthanarax P, Bean S, Mellins J. Pemphigus vegetans of Hallopeau. Arch Dermatol 1977; 113: 942-945.

2. Downie J, Dicostanzo D, Cohen S. Pemphigus vegetans-Neumann variant associated with intranasal heroin abuse. J Am Acad Dermatol 1998; 39: 872-875.

3. Du Vivier A. Atlas de dermatología clínica. 2a ed. Madrid: Mosby, 1995: 17.14-17.15.

4. James WD, Arnold HL, Odom RB. Chronic blistering or pustular dermatoses. In: Andrew’s. Diseases of the skin: Clinical Dermatology. 8th ed. Philadelphia: WB Saunders, 1990: 539.

5. Parodi A, Stanley J, Ciaccio M, Rebora A. Epidermal antigens in pemphigus vegetans. Report of a case. Br J Dermatol 1988; 119: 799-802.

6. Pearson R, O’Donoghue M, Kaplan S. Pemphigus vegetans, Its relationship to eosinophilic spongiosis and favorable response to dapsone. Arch Dermatol 1980; 116: 65-68.

7. Lever WF. Enfermedades vesiculares y ampollares no infecciosas. En: Lever WF, Schaumburg-Lever G. Histopatología de la piel. 7a ed. Buenos Aires: Intermédica, 1991: 115-116.

8. Hashizume H, Iwatsuki K, Takigawa M. Epidermal antigens and complement-binding anti-intercellular antibodies in pemphigus vegetans, Hallopeau type. Br J Dermatol 1993; 129: 739-743.

9. Hashimoto T, Ogawa M, Konohana A, Nishikawa T. Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources. J Invest Dermatol 1990; 94: 327-331.