Osatinsky R, Desimone IV, Garnek L

Language: Spanish
References: 13
Page: 90-92
PDF size: 33.90 Kb.

ABSTRACT

Examination of the proteins in plasma can provide information reflecting disease states in many different organ systems. Protein electrophoresis separates the globulins from albumin and resolves the major proteins serum into patterns that may by highly specific for some diseases. There is much to be appreciated from visual inspections of an electrophoretogram of proteins, because the human eye is highly efficient at detecting subtle variations in individual proteins as well as alterations in protein patterns. Identification of these patterns is a useful screening method to be followed by more specific confirmatory procedures to identify and quantitate aberrant protein band. There are three gamma globulin patterns: polyclonal, monoclonal and oligoclonal. We studied 2,729 adults healthy populations between 20 and 65 years old, and observed that 14.58% presents oligoclonal patterns confirmed by immunofixation (IF) test. This patterns are almost related to the presence of autoimmune disease, chronic infections, immunecomplexes diseases, chronic hepatitis and some positive HIV patients. The importance to differentiate oligoclonal bands from the monoclonal is that monoclonal bands are almost a malignant disease and the patients diagnostic and prognostic is very different.

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