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>Journals >Revista de Investigación Clínica >Year 2011, Issue 2

Schwarz-Cruz-y-Celis Á, Meléndez-Zajgla J
Cancer stem cells
Rev Invest Clin 2011; 63 (2)

Language: Inglés
References: 46
Page: 179-186
PDF: 283.58 Kb.

Full text


There are two hypotheses that explain tumor progression. The first one, the stochastic hypothesis, assumes that any cell within a tumor has the capacity to form and maintain the tumor mass. The second, the so-called hierarchical hypothesis, suggests the existence of a group of cells with a stem phenotype which, like in normal tissues, preserves tumors through a continuous production of progeny. These stem cells are in a particular niche, have a higher resistance to chemotherapy and radiotherapy, and are also capable of invading and migrating to other tissues. This review describes the cancer stem cells (CSCs), their function inside a tumor and the current knowledge about these cells.

Key words: Cancer, Cancer stem cells, Self-renewal, Differentiation, Therapeutic resistance.


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