>Year 2012, Issue 4
Athie AAJ, Gómez SJ, Zárate MJ, Sanabria GMA, Díaz GGA, Correa RJM, Robles LLPA, Athie GJA, Athie GC
Gastrointestinal carcinoid tumors, experience in “Médica Sur”
Cir Gen 2012; 34 (4)
PDF: 4. Kb.
Objective: To evaluate the cases of gastrointestinal carcinoid tumors in the Hospital y Fundación Clínica Médica Sur, and to compare them with reports in the literature.
Setting: Hospital y Fundación Clínica Médica Sur (third level health care center).
Design: Retrospective, cross-sectional, descriptive, observational study.
Statistical analysis: Percentage as summary measure for qualitative variables.
Material and methods: We reviewed 19 cases of pathology samples from the Hospital y Fundación Clínica Médica Sur.
Results: In this report we present 19 cases of patients diagnosed with gastrointestinal carcinoid tumors found in endoscopically taken biopsy samples or in postsurgical pieces. Histologically, similar tumor cells were observed with scarce granular eosinophilic cytoplasm or rounded spotted nucleus. Variations in nuclear and cellular size were minimal and mitoses were rare. Cell growth was predominantly submucous extending to the muscular and serosa layer in some cases. Twelve corresponded to women and seven to men. Average age was of 47 years. The organs most frequently affected were the stomach and the cecal appendix, the least frequent ones were the duodenum and the liver.
Conclusion: Women predominated, constituting 63% of cases, mean age of women was of 49 years, coinciding with the literature. We found an increased incidence of tumors in the stomach and appendix.
||Gastrointestinal tumors, carcinoid tumors, case report, carcinomas.
Modlin IM, Shapiro MD, Kidd M, Eick G. Siegfried oberndorfer and the evolution of carcinoid disease. Arch Surg 2007; 142: 187-197.
Varas-Lorenzo MJ, Muñoz-Agel F, Espinós-Pérez JC, Bardají-Bofill M. Gastrointestinal carcinoid tumors. Rev Esp Enferm Dig 2010; 102: 533-537.
Borch K, Ahrén B, Ahlman H, Falkmer S, Granérus G, Grimelius L. Gastric carcinoids: biologic behavior and prognosis after differentiated treatment in relation to type. Ann Surg 2005; 242: 64-73.
Oberg KE. The management of neuroendocrine tumors: current and future medical therapy options. Clin Oncol (R Coll Radiol) 2012; 24: 282-293.
Chambers AJ, Pasieka JL, Dixon E, Rorstad O. The palliative benefit of aggressive surgical intervention for both hepatic and mesenteric metastases from neuroendocrine tumors. Surgery 2008; 144: 645-651.
Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 2008; 9: 61-72.
Bendelow J, Apps E, Jones LE, Pston GJ. Carcinoid syndrome. Eur J Surg Oncol 2008; 34: 289-296.
Gosset A, Masson P. Tumeurs endocrines se l’appendice. Presse Med 2009; 25: 237-240.
Arnold R. Endocrine tumours of the gastrointestinal tract. Introduction: definition, historical aspects, classification, staging, prognosis and therapeutic options. Best Pract Res Clin Gastroenterol 2005; 19: 491-505.
Lembeck F. Current status of carcinoid research; pharmacological report. Krebsarzt 1958; 13: 196-202.
Dayal Y. Gl-NETs-uniform but also diverse. Endocr Pathol 2007; 18: 135-140.
Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063-3072.
Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumours. Cancer 2003; 97: 934-959.
de Herder WW. Tumours of the midgut (jejunum, ileum and ascending colon, including carcinoid syndrome). Best Pract Res Clin Gastroenterol 2005; 19: 705-715.
Akerstrom G, Hellman P. Surgery on neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab 2007; 21:87-109.
Granberg D, Oberg K. Neuroendocrine tumours. Cancer Chemother Biol Response Modif 2005; 22: 471-483.
Kloppel G, Anlauf M. Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of the gastrointestinal tract. Best Pract Res Clin Gastroenterol 2005; 19: 507-517.
Delle Fave G, Capurso G, Milione M, Panzuto F. Endocrine tumours of the stomach. Best Pract Res Clin Gastroenterol 2005; 19: 659-673.
Bordi C, Caruana P, D’Adda T, Azzoni C. Smooth muscle cell abnormalities associated with gastric ECL cell carcinoids. Endocr Pathol 1995; 6: 103-113.
Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B, et al. Well-differentiated gastric tumors/carcinomas. Neuroendocrinology 2006; 84: 158-164.
Woodside KJ, Townsend CM Jr, Mark Evers B. Current management of gastrointestinal carcinoid tumors. J Gastrointest Surg 2004; 8: 742-756.
Schindl M, Kaserer K, Niederle B. Treatment of gastric neuroendocrine tumors: the necessity of a type-adapted treatment. Arch Surg 2001; 136: 49-54.
Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology 1993; 104: 994-1006.
>Year 2012, Issue 4