Olmedo-Canchola VH, Enters-Altés J, del Angel-Cruz RE, Rosas-Heredia ML

Language: Spanish
References: 3
Page: 159-163
PDF size: 332.31 Kb.

ABSTRACT

In Mexico are four Sul/Big mixtures: Glib/Met, Clor/Met,Glib/Fen and Glim/Met. This last one was used for evaluate the effectiveness of this combination in comparison to Sul/Big. Our study included 108 patients who received an equal doses of glimepirida-metformina instead of Sul/Big. We excluded patients that had been used Glim/Met for the last two months, but we included those whose HbA1c levels were between 8% and 10% for the last six months, and finally, patients who developed ketoacidosis or with glycemic over 250 mg/dL were eliminated. The age average was 61.47 years in women and 58.55 in men; the fasting glucose average was 166-mg/dL for both groups. All the patients presented cholesterol seric levels and triglycerides seric levels over 200 mg/dL. We proceeded to evaluate four bimestrial periods (0,1,2 & 3), in which we founded that, in the beginning of the study, the plasmatic HbA_1c levels showed an average of 8.9% and during the fourth period (17^th- 24^th week) the result was a 7.5%, it means a diminished of 1.4%.

REFERENCES

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2. Mooradian A. Cardiovascular disease in Diabetes Mellitus type 2. Arch Intern Med 2003; 163:33-40.

3. Villaseñor A, Lozano O, Escalante A, y col. Uso de combinaciones fijas en el tratamiento de la diabetes mellitus tipo 2. Revista de Endocrinología y Nutrición 2002;10(Supl. 1).