Araujo-Meléndez J, Sifuentes-Osornio J, Bobadilla-del-Valle JM, Aguilar-Cruz A, Torres-Ángeles O, Ramírez-González JL, Ponce-de-León A, Ruiz-Palacios GM, Guerrero-Almeida ML

Language: English
References: 15
Page: 541-545
PDF size: 147.69 Kb.

ABSTRACT

In Mexico, Q fever is considered a rare disease among humans and animals. From March to May of 2008, three patients were referred, from the state of Hidalgo to a tertiary-care center in Mexico City, with an acute febrile illness that was diagnosed as Q fever. We decided to undertake a cross sectional pilot study to identify cases of acute disease in this particular region and to determine the seroprevalence of Coxiella burnetii among healthy individuals with known risk factors for infection with this bacteria. Q fever was defined according to the Centers for Disease Control and Prevention criteria. All subjects were interviewed for signs and symptoms of the disease, demographic and household characteristics and occupational exposure to cattle. Blood samples were taken from hospitalized and outpatients with symptoms suggestive of Q fever, as well as from asymptomatic individuals with direct and daily exposure to cattle (slaughterers, butchers, farmers, shepherds and veterinarians) in the five municipalities. We report the occurrence of 17 cases with positive antibodies against C. burnetii in a rural area of central Mexico; eight cases had clinical criteria of acute Q fever disease. Results from this pilot study underscore the need for active surveillance programs and comprehensive studies to further define the prevalence and risk factors associated with the disease in Mexico, to know more about its clinical presentation and to characterize bacterial factors involved in its pathogenesis.

REFERENCES

1. Schimmer B, Dijkstra F, Vellema P, Schneeberger PM, Hackert V, Schegget R, et al. Sustained transmission of Q fever intensive in the South of the Netherlands, 2009. Euro Surveil 2009; 14: 1-3.

2. Bosnjak E, Hvasser AMSW, Villumsen S, Nielsen H. Emerging evidence for Q fever in Humans in Denmark: role of contact with dairy cattle. Clin Microbiol Infect 2010; 16: 1285-8 [Epub ahead of print 2009, Oct. 14].

3. Maurin M, Raoult D. Q fever. Clin Microbiol Rev 1999; 12: 518-53.

4. Parker NR, Barralet JH, Bell AM. Q fever. Lancet 2006; 367: 679-88.

5. Hartzell JD, Wood-Morris RN, Martinez LJ, RF Trotta. Q fever: epidemiology, diagnosis, and treatment. Mayo Clin Proc 2008; 83: 574-9.

6. Official Gazette of the Federation. Mexico. First Section, 2007, Sept. 20: 7-15.

7. Anderson AD, Kruszon-Moran D, Loftis AD, McQuillan G, Nicholson WL, Priestley RA, et al. Seroprevalence of Q fever in the United States, 2003-2004. Am J Trop Med Hyg 2009; 81: 691-4.

8. Q fever case report. Centers for Disease Control and Prevention. 55.1 Rev. 2/2008.

9. Varela G. New rickettsial diseases found in Mexico: Q fever and trench fever. Gac Med Mex 1955; 85: 275-9.

10. Varela G, Velasco R. Studies on Q fever in the Mexican Republic. Rev Invest Sal Pub 1966; 26: 301-06.

11. González-Canudas JA, Vega B, Nellen-Hummel H, Lisker-Halpert A, Laredo-Sánchez F. Granulomatous hepatitis caused by Q fever. Gac Med Mex 1997; 133: 475-7.

12. Sahagún-Sánchez G, Cotter-Lemus L, Zamora-González C, Reyes PA, Ramírez S, Buendia A. Coxiellaburnetii endocarditis. A case report of the first case diagnosed in Mexico. Arch Inst Cardiol Mex 1998; 68: 322-7.

13. Enserink M. Questions abound in Q-fever explosion in the Netherlands. Science 2010; 327: 266-7.

14. Koch A, Svendsen CB, Christensen JJ, Bundgaard H, Vindfeld L, Christiansen CB, et al. Q fever in Greenland. Emerg Infect Dis 2010; 16: 511-13.

15. Raoult D. Reemergence of Q fever after 11 September 2001. Clin Infect Dis 2009; 48: 558-9.