2013, Number 3
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Rev Med Inst Mex Seguro Soc 2013; 51 (3)
Male hormonal profi le in workers exposed to toluene in an industrial packaging plant
Miranda-Figueroa G, Paz-Román MP, Aguilar-Madrid G, Juárez-Pérez CA, Basurto-Acevedo L, Haro-Garcíae L
Language: Spanish
References: 21
Page: 270-275
PDF size: 77.33 Kb.
ABSTRACT
Objective: to identify changes in the male hormonal profile (MHP), consisting
of luteinizing hormone (LH), follicle-stimulating hormone (FSH)
and testosterone, in workers exposed to toluene.
Methods: cross-sectional study that included 42 workers, formed in two
groups: with high and low exposure to toluene (HET and LET, respectively);
the hippuric acid in urine, and the serum concentration in FSH,
LH, and testosterone were measured.
Results: hippuric acid in subjects with LET was 2.53 ± 1.20 g/g creatinine,
and with HET: 6.31 ± 3.83 g/g creatinine (
p = 0.02). Seric FSH
concentration was 5.12 ± 0.77 and 3.55 ± 0.3 mU/mL (
p = 0.02) in LET
and HET, respectively; LH: 2.66 ± 0.45 and 2.77 ± 0.21 (
p = 0.81), and
testosterone 3.91 ± 0.34 and 4.86 ± 0.23 ng/mL (
p = 0.04). By regression
analysis, the correlation coefficient of FSH with hippuric acid was
r = –0.33 (
p = 0.031), with coeffi cient of determination of 11 %; the LH
correlation coeffi cient was
r = –0.037 (
p = 0.88) and 0.05 %, respectively;
and the one for testosterone was
r = 0.61 (
p = 0.0001) and 34 %.
Conclusions: in HET group, FSH and LH serum levels diminished; testosterone
shows an opposite response, perhaps explained by a different
sensitivity of the male gonads exposed to toluene.
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