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2001, Number 3

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Arch Cardiol Mex 2001; 71 (3)

Toxicity and hypotensor effect of Oxoborolidinona of L-arginine and its modulation by methylene blue as compared to L-arginine

Bravo ÁME, Araujo ÁJM, Bustamante QA, Trujillo FJG

Language: Spanish
References: 16
Page: 193-198
PDF size: 62.53 Kb.


ABSTRACT

Nitric oxide is synthesized by constitutive oxide nitric synthase from the guanidine group of L-arginine. L-arginine, oxoborolidinone of L-arginine, nitrite and nitrate showed dose-dependent hypotensive effects after injection via the femoral vein in Wistar rats. The hypotensive effects were shifted to the right after treatment with methylene blue, which is a synthetic phenothiazine inhibitor of guanylate cyclase. Oxoborolidinone of L-arginine had high hypotensive effects with an effective half dose of 10 ηhmoles kg-1 and of μmoles kg-1 for methylene blue. Methylene blue also attenuated the toxic effects of all the tested compounds.


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