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2013, Number 3

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Rev Mex Pediatr 2013; 80 (3)

Adenovirus as a causal agent of acute gastroenteritis in children

Martina LM, Iglesias LJ, Bernárdez ZI, Rendón-Macías ME
Full text How to cite this article

Language: Spanish
References: 51
Page: 98-104
PDF size: 70.84 Kb.


Key words:

Human adenovirus, gastroenteritis.

ABSTRACT

Objective: Identify early adenoviruses in children with acute gastroenteritis.
Methods: Retrospective study that included patients under 16 years with diagnosis of infectious gastroenteritis in a four year period, 1619 subjects were found; 501 were tested for adenoviruses in stool.
Results: The frequency of adenoviruses was 9.9%. The disease prevailed in infants. It had a subacute evolution, mainly found in spring; the most characteristic symptom was a profuse, watery and mucous diarrhea with mean duration of 4 days. Vomiting was present in 40 (80%) patients and was brief but intense half the patients presented fever, abdominal pain and bloating. Only one presented with severe dehydration. Normal leukocyte count with monocitosis and lymphocytosis were mainly observed in the CBC.
Conclusion: adenoviruses are important causal agents of acute gastroenteritis in children under two years. Rapid stool test helps us have a precocious diagnosis and avoid antibiotic overuse.


REFERENCES

  1. World Health Organization [homepage on the internet]. Media Centre: Fact Sheet no 330 [updated August 2009]. Available from: http://www.who.int/mediacentre/factsheets/fs330/en/index.html

  2. DGIS. Principales causas con lista mexicana 1998-2010/CONAPO. Proyecciones de los nacimientos estimados de México CONTEO 2005 (1990-2012).

  3. Hernández-Cortez C, Aguilera-Arreola MG, Castro-Escarpulli G. Situación de las enfermedades gastrointestinales en México. Enf Inf Microbiol 2011; 31(4): 137-151.

  4. Blacklow NR, Greenberg HB. Medical progress: viral gastroenteritis. New Engl J Med 1991; 325: 252-263.

  5. Girard MP, Steele D, Chaignat CL, Kieny MP. A review of vaccine research and development: human enteric infections. Vaccine 2006; 24: 2732-2750.

  6. de Jong JC, Wigand R, Kidd AH, Wadell G, Kapsenberg JP, Muzerie CJ et al. Candidate Adenoviruses 40 and 41: Fastidious adenoviruses from human infant stool. J Med Virol 1983; 11: 215-231.

  7. Zaghloul MZ. Adenovirus serotypes (40,41) as a cause of gastroenteritis. Air Water Borne Dis 2012; 1: 1-2.

  8. Jones MS, Harrach B, Ganac R et al. New adenovirus species found in a patient presenting with gastroenteritis. J Virol 2007; 81: 5978-5784.

  9. Bányai K, Martella V, Meleg E, Kisfali P, Peterfi Z, Benko M et al. Searching for HAdV-52, the putative gastroenteritis-associated human Adenovirus serotype in southern Hungary. New Microbiol 2009; 32: 185-188.

  10. Manjarrez ME, Rosete DP, Navas A, Santiago J, Calderón I, Chapela R. Adenovirus en un grupo de pacientes con infección respiratoria aguda. Rev Inst Nal Enf Resp Mex 2002; 15(2): 64-69.

  11. Amato-Almanza M, Bautista LVM, Pérez-Cano HJ, Mejía-López H. Polimorfismo del gen TLR2 como factor de riesgo en la infección oftálmica por adenovirus. Rev Mex Oftalmol 2009; 8(6): 381-384.

  12. Treviño M, Prieto E, Peñalver D, Aguilera A, García-Zabarte A, García-Riestra C et al. Diarrea por adenovirus y astrovirus en pacientes inmunodeficientes hospitalizados. Enferm Infecc Microbiol Clin 2001; 19(1): 7-10.

  13. Puerto FI, Polanco GG, González MR, Zavala JE, Ortega G. Role of Rotavirus and enteric Adenovirus in acute paediatric diarrhoea at an urban hospital in Mexico. Trans R Soc Trop Med Hyg 1989; 83(3): 396-398.

  14. Ciruela P, Izquierdo C, Oviedo M, Domínguez A. Rotavirus y adenovirus 40-41 como causantes de gastroenteritis infantil. Vacunas 2004; 5: 12-16.

  15. Dey SK, Hoq I, Okitsu S, Hayakawa S, Ushijima H. Prevalence, seasonality, and peak age of infection of enteric Adenoviruses in Japan: 1995-2009. Epidemiol Infect 2012; 20: 1-3.

  16. Sinclair MI, Hellard ME, Wolfe R, Mitakakis TZ, Leder K, Fairley CK. Pathogens causing community gastroenteritis in Australia. J Gastroenterol Hepatol 2005; 20: 1685-1690.

  17. Rodriguez-Baez N, O’Brien R, Qui SQ. Astrovirus, adenovirus and rotavirus in hospitalized children: prevalence and association with gastroenteritis. Pediatr Gastroenterol Nutr 2002; 35(1): 64-68.

  18. Simpson R, Aliyu S, Iturriza-Gómara M, Desselberger U, Gray J. Infantile viral gastroenteritis: on the way to closing the diagnostic gap. J Med Virol 2003; 70: 258-262.

  19. Magwalivha M, Wolfaardt M, Kiulia NM, van Zyl WB, Mwenda JM, Taylor MB. High prevalence of species D human adenoviruses in fecal specimens from urban kenyan children with diarrhea. J Med Virol 2010; 82: 77-84.

  20. Andreassi MSA, Cardoso DDP, Fernandez SM, Tozetti IA, Tavares-Borges AM, Souza-Fiaccadori F et al. Adenovirus, Calicivirus and Astrovirus detection in fecal samples of hospitalized children with acute gastroenteritis from Campo Grande, Brasil. Inst Oswaldo Cruz 2008; 103(7): 741-744.

  21. Oh DY, Gaedicke G, Schreirer E. Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol 2003; 71: 82-93.

  22. Tayeb H, De la Cruz D, Al-Qahtani A, Al-Ahdal MN, Carter MJ. Enteric viruses in pediatric diarrhea in Saudi Arabia. J Med Virol 2008; 80: 1919-1929.

  23. Aminu M, Ahmad AA, Umoh JU, de Beer MC, Esona MD, Steele AD. Adenovirus infection in children with diarrhea in northwestern Nigeria. Ann Afr Med 2007; 6(4): 168-1673.

  24. Nguyen TA, Yagyu F, Okame M, Phan TG, Trinh QD, Yan H et al. Diversity of viruses associated with acute gastroenteritis in children hospitalized with diarrhea in Ho Chi Minh City, Vietnam. J Med Virol 2007; 79: 582-590.

  25. Lennon G, Cashman O, Lane K, Cryan B, O’Shea H. Prevalence and characterization of enteric adenoviruses in the south of Ireland. J Med Virol 2007; 79: 1518-1526.

  26. Gonzalez GG, Liprandi F, Ludert JE. Molecular epidemiology of enteric viruses with sporadic gastroenteritis in Valencia, Venezuela. J Med Virol 2011; 83: 1972-1982.

  27. Banyai K, Kisfali P, Bogdan A, Martella V, Melegh B, Erdman D et al. Adenovirus gastroenteritis in Hungary 2003-2006. Eur J Clin Microbiol Infect 2009; 28: 997-999.

  28. Sdiri-Loulizi K, Gharbi-Khelifi H, de Rougemont A, Hassine M, Chouchane S, Sakly N et al. Molecular epidemiology of human astrovirus and adenovirus serotypes 40/41 strains related to acute diarrhea in tunisian children. J Med Virol 2009; 81: 1895-1902.

  29. Hamkar R, Yahyapour Y, Noroozi M, Nourijelyani K, Jalilvand S, Adibi L et al. Prevalence of rotavirus, adenovirus and astrovirus infections among patients with acute gastroenteritis in northern Iran. Iranian J Pub Health 2010; 39(2): 45-51.

  30. Silva PA, Stark K, Mockenhaupt FP, Reither K, Weitzel T, Ignatius R et al. Molecular characterization of enteric viral agents from children in northern region of Ghana. J Med Virol 2008; 80: 1790-1798.

  31. Carraturo A, Catalani V, Tega L. Microbiological and epidemiological aspects of Rotavirus and enteric adenovirus infections in hospitalized children in Italy. New Microbiol 2008; 31(3): 329-336.

  32. Kittigul L, Pombubpa K, Taweekate Y, Yeephoo T, Khamrin P, Ushijima H. Molecular characterization of rotaviruses, noroviruses, sapovirus and adenoviruses in patients with acute gastroenteritis in Thailand. J Med Virol 2009; 81: 345-353.

  33. Arrivi F, Donia D, Gabrieli R, Petrinca AR, Cenko F, Bebeci D et al. Influence of enteric viruses on gastroenteritis in Albania: epidemiological and molecular analysis. J Med Virol 2007; 79: 1844-1849.

  34. Tran A, Talmud D, Lejeune B, Jovenin N, Renois F, Payan C et al. Prevalence of rotavirus, adenovirus, norovirus and astrovirus infections and coinfections among hospitalized children in northern France. J Clin Microbiolog 2010; 48(5): 1943-1946.

  35. Bicer S, Tunca-Sahin G, Koncay B, Gemici H, Siraneci R, Öztürk NY et al. Incidence assessment of rotavirus and adenovirus associated acute gastroenteritis cases in early childhood. Le Infezioni in Medicina 2011; 2: 113-119.

  36. van Maarseveen NM, Wessels E, de Brouwer CS, Vossen AC, Claas EC. Diagnosis of viral gastroenteritis by simultaneous detection of adenovirus, astrovirus, rotavirus, norovirus and sapovirus in 2 internationally controlled multiplex real time PCR assays. J Clin Virol 2010; 49(3): 205-210.

  37. Dey RS, Ghosh S, Chawla-Sarkar M, Manna B, Ramamurthy T, Panchalingam S et al. Circulation of a novel pattern of infections by enteric adenovirus serotype 41 among children below 5 years of age in Kolkata, India. J Clin Virol 2011; 49(2): 500-505.

  38. Goncalves G, Gouveia E, Mesquita JR, Almeida A, Ribeiro A, Rochapereira J et al. Outbreak of acute gastroenteritis caused by adenovirus type 41 in a kindergarten. Epidemiol Infect 2011; 139: 1672-1675.

  39. Zhand S, Chen TH, Wang J, Dong C, Pan J, Moe C et al. Symptomatic and asymptomatic infections of rotavirus, norovirus and adenovirus among hospitalized children in Xi’an, China. J Med Virol 2011; 83: 1476-1484.

  40. Johansson ME, Uhnoo I, Svensson L, Pettersson CA, Wadell G. Enzyme-linked immunosorbent assay for detection of enteric adenovirus 41. J Med Virol 1985; 17(1): 19-27.

  41. Staatz G, Alzen G, Heimann G. Gastrointestinal infection, most common cause of invagination in childhood: results of a 10-year study. Klin Padiatr 1998; 210: 61-64.

  42. Feeney SA, Armstrong VJ, Mitchell SJ, Crawford L, McCaughey C, Coyle PV. Development and clinical validation of Multiplex TaqManW Assays for rapid diagnosis of viral gastroenteritis. J Med Virol 2011; 83: 1650–1656.

  43. Uhnoo I, Wadell G, Svensson L, Johansson ME. Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children. J Clin Microbiol 1984; 20(3): 365-372.

  44. Newman RD, Grupp-Phelan J, Shay DK, Davis RL. Perinatal risk factors for infant hospitalization with viral gastroenteritis. Pediatrics 1999; 103: 3.

  45. Kotloff KL, Losonsky GA, Glenn Morris J, Wasserman SS, Singh-Naz N, Levine MM. Enteric adenovirus infection and childhood diarrhea: an epidemiologic study in three clinical settings. Pediatrics 1989; 84: 219-225.

  46. Wood DJ. Adenovirus gastroenteritis. BMJ 1988; 296: 229-230.

  47. Grimwood K, Forbes DA. Acute and persistent diarrhea. Pediatr Clin N Am 2009; 56: 1343–1361.

  48. King CK, Glass R, Bresee JS et al. Managing acute gastroenteritis among children. Oral rehydration, maintenance, and nutritional therapy. Morb Mortal Wkly Rep 2003; 52(16): 1-16.

  49. Alhashimi D, Al-Hashimi H, Fedorowicz Z. Antiemetics for reduced vomiting related to acute gastroenteritis in children and adolescents. Cochrane Database Syst Rev 2009; (2): CD005506.

  50. Abba K, Sinfield R, Hart CA, Garner P. Antimicrobial drugs for persistent diarrhea of unknown or non-specific cause in children under six in low and middle income countries: systematic review of randomized controlled trials. BMC Infect Dis 2009; 9: 24-31.

  51. Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE et al. Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004–2006. CID 2007; 45: 1120–1130.




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Rev Mex Pediatr. 2013;80