Treviño BA, Baca ER, Meza CC, Chávez ZMI, Gamboa MVE

Language: Spanish
References: 0
Page: 22-27
PDF size: 512.64 Kb.

ABSTRACT

The glomerular filtration rate (GF) is traditionally measured as the renal clearance of a substance or marker from plasma. lt is extremely important because: In young adults the GFR is 120 130 mLmin/ 1.73 m² of body surface and progressively declines with age. The early detection of GFR abnormalities allows providing treatment. lt allows properly adjusting the drug doses. lt helps measure the progression of renal disease and assess treatments. lt helps decide when renal replacement therapy is necessary. In the epidemiologic practice, creatinine based fórmulas are used to estimate the GF, with the Cockroft Gault formula being the most common one. Another formulas to determine the GF are the MDRD (Modification of Diet in Renal Disease). The serum cystatin C concentration correlates well with creatinine clearance. This paper compares the GF estimates using 24 hour urinary creatinine clearance correlating them with the following formulas: Cockroft Gault, MDRD, the new CKD EPI fórmula and the cystatin C measurements. In the study group creatinine clearance was 62 ± 27 mLmin (Cl 95%); with MDRD 61 ± 24 mLmin (Cl 95%); w ith eKD EPI 64 ± 26 mLmin (Cl 95%), and GF calculated w ith the Cockroft Gault fórmula was 72 ± 27 mLmin (Cl 95%), and with cystatin C 83 ± 38 mLmin (Cl 95%). The results of this study show that cystatin C is a good marker to estimate GF in patients at different stages of chronic kidney disease.