2012, Number 3
Mecanismos neuroendocrinos de la cirugía metabólica en el tratamiento de la diabetes mellitus tipo 2
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ABSTRACTIn Mexico as well an in other countries the epidemiologic reports indicate that the chronic deceases still occupied the first place in morbidity and mortality. Of all of them, type 2 diabetes mellitus (T2DM) is one with the more growing incidence in adult and productive population. Prevalence of T2DM in 2002 was 2.8% word wide and is estimated that it will increase to 4.4% in 2030, in every group of age and even if risks factors such as obesity maintain constant; mainly because habits such as hypercaloric diets and sedentary. In 2011 there were 366,000,000 diabetics reported worldwide and is expected to be approximately about 522,000,000 in 2030. Such situation forces us to take initiatives with the purpose of offering treatments that would give an adequate control, making of it a priority in public health. More than 60% of the people with T2DM are obese and that is why losing weight procedures are an attractive but defying therapeutic option. Gastric bypass (GB) is associated to higher rates of hyperglycemia remission, important fasting basal glucose levels reduction and diminish HbA1c compare to medical treatment by itself. So, when pharmaceutical and conductual interventions fail, metabolic surgery is and efficient possibility of T2DM full remission and offer a unique opportunity to better understand its pathophysiology.
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