Romer-Romo JI, Marcelín-Jiménez G, Ángeles-Moreno ACP

Language: Spanish
References: 7
Page: 193-203
PDF size: 173.93 Kb.

ABSTRACT

Based on preclinical and clinical studies, previously performed with the combination of lysine clonixinate/tramadol, which demonstrated synergy in the analgesic effect of this combination and its safety, a tablet for oral administration has developed and marketed with the combination of 25 mg tramadol hydrochloride 125 mg of lysine clonixinate. In the present study, it has been proposed to confirm the synergistic effect previously observed with the combination in the treatment for the management f various types of pain expecting to find fewer side events associated with each active due to a lower dose of each drug. It was suggested to conduct an observational analysis on prescribing the previously mentioned combination in a universe of 1,466 cases handled by 500 physicians specializing in Orthopedics and Traumatology, Internal Medicine, Urology, Gastroenterology, Gynecology, Dentistry and Oncology; clinical patient data was reviewed with various diagnoses, which show different processes of acute or chronic pain. Patients were given the treatment orally, a tablet of the combination of 25 mg tramadol hydrochloride 125 mg of lysine clonixinate every 8 h, and at the end of 5 days of treatment, patients assessed their improvement on a visual-analogue scale (VAS), and that the physicians questioned the presence of adverse reactions. Regarless of the type of pain, most people reported and improvement in the perception of the quality, intensity and frequency of pain.

REFERENCES

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