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2012, Number 1

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Rev Hosp Jua Mex 2012; 79 (1)

Omental transplantation on the carotid bifurcation and anterior perforated space for Alzheimer’s disease

Rafael H, Mego R, Valadez MT

Language: Spanish
References: 26
Page: 25-30
PDF size: 280.79 Kb.


ABSTRACT

Background. Every time is increasing evidences that cerebral atherosclerosis is associated with an increased risk for Alzheimer’s disease (AD). Material and methods. We attended to 152 patients with AD (women, 124 cases and men 28), in which the 94% were non-genetic cases. In all patients, the mild degree was characterized by 1) Progressive loss of recent memory and 2) Behavioral and personality changes, both data as initial symptoms. Computerized tomography scans and magnetic resonance image revealed 1) Normal cerebral parenchyma or slight cerebral atrophy, and 2) Atherosclerosis at the supraclinoid carotids. Twenty-three patients (moderate AD in 18 cases and mild AD in 5) received omental transplantation on the carotid bifurcation and surrounding zones. During surgery we found moderate or severe atherosclerosis in the supraclinoid carotids; some exsanguinated anterior perforating arteries, and other branches with residual blood flow centripetal to the site of origin. Results. In all mild AD patients there were complete reversal of symptoms since the first days after surgery; meanwhile in moderate AD patients only there were neurological improvement. Conclusions. These results indicate that the etiologic agent of AD is of ischemic origin initiated in the intraparenchymal territory of the anterior choroidal and anterior perforating arteries caused by atherosclerosis.


REFERENCES

  1. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery W. Brain infarction and the clinical expression of Alzheimer disease: the nun study. JAMA 1997; 277(10): 813-7.

  2. Pratico D, Delanty N. Oxidative injury in disease of the central nervous system: Focus on Alzheimer’s disease. Am J Med 2000; 109: 577-85.

  3. Rafael H. Cerebral atherosclerosis and oxidative stress in some challenging disease. J Neurol Sci (Turk) 2004; 21(4): 343-9. Available from www.jns.dergisi.org

  4. Rafael H, Mego R, Cortés R. Enfermedad de Alzheimer. Una correlación entre la etapa temprana y aterosclerosis del polígono de Willis. Rev Climaterio (Méx) 1999; 3(13): 1-7.

  5. Rafael H. Cerebral atherosclerosis and oxidative stress in Alzheimer’s disease. J Alzheimer Dis 2003; 5(6): 479-80.

  6. Goldsmith HS. Omental transposition for Alzheimer’s disease. Neurol Res 1996; 18(4): 103-8.

  7. Saper CB. Cholinergic system. In: Paxinos G (ed.). The Human Nervous System. San Diego: Academic Press, Inc.; 1990: 1095-113.

  8. Rafael H, Mego R, Moromizato P, Espinoza M, Valadez MT. Trasplante de epiplón para la enfermedad de Alzheimer. Rev Climaterio (Méx) 2000; 3(14): 83-9. Disponible en: www.nietoeditores.com.mx

  9. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA work group under the auspices of department of Health and human services task force on Alzheimer’s disease. Neurology 1984; 34: 939-44.

  10. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger- Gateau P, Cummings J, Delacourte A, Galasko D, et al. Research criteria for the diagnosis of Alzheimer’s disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6(8): 734-46.

  11. Rafael H, Cortés R, Valadez MT. Early clinical features of Alzheimer’s disease. J Neurol Sci (Turk) 2003; 20(4): 222-7. Available from www.jns.dergisi.org

  12. Rafael H. Onset of the symptoms in Alzheimer’s disease. Med Sci Monit 2008; 14(10): LE 15-16. Available from: www.medscimonit.com

  13. Rafael H, Mego R, Moromizato P, García W, Rodriguez J. Omental transplantation for type 2 diabetes mellitus: A report of two cases. Case Rep Clin Prac Rev 2004; 5: 481-486. Available from: www.amjcaserep.com

  14. Rafael H. Neural transplantation. J Neurosurg 2006; 104: 336-7.

  15. Rafael H, Mego R, Moromizato P, Espinoza M. Omental transplantation for Alzheimer’s disease. Neurol India 2000; 48(4): 319-21. Available from: www.neurologyindia.com

  16. Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology 1967; 17(5): 427-44.

  17. Jellinger KA. Traumatic brain injury as a risk factor for Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2004; 75(3): 511-2.

  18. Hoffman M, Muniz J, Carroll E, et al. Cryptococcal meningitis misdiagnosed as Alzheimer’s disease: Complete neurological and cognitive recovery with treatment. J Alzheimer Dis 2009; 16(3): 517-20.

  19. Ramirez-Bermudez J, Higuera J, Sosa AL, Lopez-Meza E, Lopez-Gomez M, Corona T. Is dementia reversible in patients with neurocysticercosis? J Neurol Neurosurg Psychiatry 2005; 76(7): 1164-6.

  20. Rafael H. Nervios craneanos. 3a. Ed. México, D.F.: Editorial Prado; 2009.

  21. García-Gómez I, Goldsmith HS, Angulo J, Prados A, Lopez- Hervás P, Cuevas B, Dujovny M, Cuevas P. Angiogenic capacity of human omental stem cell. Neurol Res 2005; 27(8): 807-11.

  22. Rafael H. Aplicación clínica del epiplón en el sistema nervioso central. Acta Med Per 2008; 25(3): 176-180. Disponible en www.cmp.org.pe/actamedica

  23. Goldsmith HS. Omental transposition to the brain for Alzheimer’s disease. In: Goldsmith HS (Ed.). The omentum: Application to brain and spinal cord. Wilton CT, Forefront Publishing Group; 2000, p. 184-97.

  24. Gonzales-Martinez JA, Bingaman WE, Toms SA, Najm IM. Neurogenesis in the postnatal human epileptic brain. J Neurosurg 2007; 107(3): 628-35.

  25. Rafael H. Therapeutic methods against aging. Turk J Geriatrics 2011; 13(2): 138-44. Available from: www.geriatri.dergisi.org

  26. Rafael H. Etiología y fisiopatología de la diabetes mellitus tipo 2. Rev Mex Cardiol 2011; 22(1): 39-44. Disponible en www.medigraphic.com




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