Cortés-Malagón EM, Torres-Lozada V, Zaldívar-Reyna O, Rodríguez-Uribe G, Serafín-Higuera NA, García-López ES, Contreras RG, Escobar-Herrera J, Reyes-Hernández OD, Sierra-Martínez M, Gariglio P, Villatoro C, Bonilla-Delgado J

Language: Spanish
References: 9
Page: 239-242
PDF size: 307.21 Kb.

ABSTRACT

Introduction. Chronic wounds are characterized by its lack of self-repairing. Material and methods. In the present work, we immuno-detected the location of β-catenin and PCNA proteins in plantar biopsies derived from the epithelization zone of DM2 patients (Wagner scale/grade 1) by immunohistochemistry. Results. Our results suggest, that β-catenin its not located in the cytoplasm or nucleus of epidermal cells from DM2 patients; however, β-catenin is located in the basal and suprabasal stratums; additionally, the suprabasal stratum contains PCNA-positive cells. Conclusion. This report supports the notion that the proliferation/ differentiation patterns are disregulated in the plantar skin of DM2 patients.

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