2003, Number 5
Gac Med Mex 2003; 139 (5)
Liver Enzyme Modification in Undernourished Rats Treated with Acetaminophen
González-Mendoza M, Vicuña-Fernández N
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Acetaminophen is used as an analgesic and antipyretic. Due to its
relative safety at therapeutic dose, it is frequently used in children
and in pregnant women. We evaluated the effect of a dose equivalent to
the therapeutic dose of Acetaminophen in undernourished rats; 72 Wistar
male rats of 18 weeks of age, with weight between 270 and 280 g, were
distributed randomly in four groups: A, normal without food restriction;
B, normal without food restriction treated with Acetaminophen (100mg/kg);
C; undernourished by food restriction and D, undernourished by food
restriction treated with Acetaminophen (100mg/kg). The results showed
decreasing of body and hepatic weight in undernourished rats and in
undernourished treated with Acetaminophen, significant decrease of
serum albumin concentration (p<0.001). It was demonstrated that
activity of the enzymes alanine aminotransferase (ALT), aspartate
aminotransferase (AST) and alkaline phosphatase significantly decreased
(p< 0.001) in the group of undernourished rats treated with
Acetaminophen compared with the other groups. We concluded that the
Acetaminophen induces hepatic lesions in undernourished rats treated
with a single non toxic dose of 100 mg/kg of weight, probably as a
consequence of the inherent susceptibility to malnutrition.
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