Villalobos GL

Language: Spanish
References: 10
Page: 251-254
PDF size: 164.15 Kb.

ABSTRACT

Bipolar Disorder has a high prevalence at any point in life and according to the World Health Organization is the 9th leading cause of disability. Diagnosis tends to be difficult and it often takes several years to do it correctly. At this time there are several molecules that have demonstrated certain efficacy in the treatment of bipolar disorder. Quetiapine is the first atypical antipsychotic to be approved as monotherapy in the treatment of bipolar disorder, manic and depressed episode and as maintenance therapy. Quetiapine has at least 5 clinical trials in bipolar depression that demonstrate its efficacy in this indication.

REFERENCES

1. Calabrese JR, Keck PE, Macfadden W, et al. A randomized, double-blind, placebocontrolled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychiatry 2005;162:1351-60

2. Hirschfeld RM, Lewis L, Vornik LA. Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry 2003;64:161- 74

3. Información para prescribir, Seroquel. Astrazeneca 2012.

4. Judd L, Akiskal HS, Schettler PJ, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 2002;59(6):530-7

5. Judd L, Akiskal HS, Schettler PJ, et al. A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Arch Gen Psychiatry 2003;60(3):216-69

6. McElroy SL, Weisler RH, Chang W, et al. A double-blind, placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression (EMBOLDEN II). J Clin Psychiatry 2010;71(2):163-74

7. Merikangas KE, Akiskal HS, Angst J, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007;64:543-52

8. Suppes T, Datto C, Minkwitz M, et al. Effectiveness of the extended release formulation of quetiapine as monotherapy for the treatment of acute bipolar depression. J Affect Disord 2010;121(1-2):106-15

9. Thase ME, Macfadden W, Weisler RH, et al. Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study). J Clin Psychopharmacol 2006;26(6):600-9

10. Young AH, McElroy SL, Bauer M, et al. A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I). J Clin Psychiatry 2010;71(2):150-6