2008, Number 2
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ABSTRACTIntroduction: The multiple sclerosis is a disease demyelinant of the nervous central system, where the oligodendrocytes produce an autoimmune physiopathogenia against the myelin. There has been reported a frequency of autoimmune disease of 29.9% in the relatives of firstly and the second degree of the patients with multiple sclerosis. Likewise the patients with multiple sclerosis have a major comorbidity with other immunological disorders as the arthritis rheumatoid, pernicious anemia, hypothyroidism autoimmune and diabetes mellitus type 1. Material and method: A observacional, transversal, descriptively and comparatively study was realized with 88 patients in the Servicio de Neurologia of the CMN “20 de Noviembre” from June, 2006 to March, 2007. The levels of T3L, T3T, T4L, T4T, antibodies anti-microsomales, anti-tiroglobulina and TSH’s levels were measured by techniques of specific radioinmunoenssay, test radioinmunometric and for an ultrasensitive method. Results: 58 (65.8%) patients presented the form appellant-sender, eight patients the primarily progressive form (9.2%). In whole, 21 patients (23.9%) presented thyroid alterations. Conclusion: The range of thyroid alteration founded (23.9%) in this study agrees with the reported in the literature, with major presence in the patients with multiple sclerosis that in the general population.
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