Martínez HR, Caro E, Gil-Valadez A , Moreno CJ, González-Garza MT, Molina-López JF, Treviño-Manllo SA, Hernández-Torre M

Language: English
References: 8
Page: 240-242
PDF size: 49.16 Kb.

ABSTRACT

The association between Amyotrophic Lateral Sclerosis (ALS) and Neurocysticercosis (NCC) has rarely been described in literature. We describe a patient with both disorders. NCC was diagnosed in a 55 year-old male patient with positive CT scan and cerebrospinal fluid (CSF) immunoassay tests. After Praziquantel treatment, he developed slurred speech, bradylalia and periods of speech arrest. He also demonstrated bulbar, upper and lower motor neuron symptomatology. Electromyography supported definite ALS diagnosis, and brain MRI confirmed the presence of NCC in motor cortices. Although the association between NCC and ALS may have occurred by chance, we hypothesize that autoimmune, apoptotic and circulatory mechanisms contributed in the development of ALS in this patient.

REFERENCES

1. Mills KR. The natural history of central motor abnormalities in amyotrophic lateral sclerosis. Brain 2003; 126: 2558-66.

2. Ringel SP, Murphy JR, Alderson MK, Bryan W, England JD, Miller RG, et al. The natural history of amyotrophic lateral sclerosis. Neurology 1993; 43(7):1316-22.

3. Rowland LP, Schneider NA. Amyotrophic lateral sclerosis. N Engl J Med 2001; 344: 1688-700.

4. Martínez HR, González GMT, Moreno CJE, Caro E, Gutiérrez JE, et al. Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Cytotherapy 2009; 11(1): 26-34.

5. Martínez HR, Rangel GRA, Arredondo EJH, Marfil A, Onofre J. Medical and surgical treatment in neurocysticercosis a magnetic resonance study of 161 cases. J Neurol Sci 1995; 130(1): 25-34.

6. Orrel RW. Understanding the causes of amyotrophic lateral sclerosis. N Engl J Med 2007; 23; 357(8): 775-88.

7. Kahn P. Cysticercosis of the central nervous system with amyotrophic lateral sclerosis: case report and review of the literature. J Neurol Neurosurg Psychiatry 1972; 35(1): 81-7.

8. Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003; 348(14): 1365-75.