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Academia Mexicana de Neurología, A.C.

2012, Number 6

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Rev Mex Neuroci 2012; 13 (6)

Clinical and electrophysiological evolution of a case of sporadic Creutzfeldt-Jakob disease

Cruz-Alcalá LE, Márquez-Padilla J, Guzmán-Guzmán JL, Cruz-Martín del Campo EE

Language: Spanish
References: 20
Page: 314-318
PDF size: 314.99 Kb.


ABSTRACT

Introduction: Creutzfeldt-Jakob disease is manifested by a rapidly progressive dementia, myoclonus and periodic sharp wave complexes in biphasic or triphasic EEG. It is required for definitive diagnosis a histopathological examination, where a characteristic feature is the spongiform lesions, neuronal loss, astrogliosis and prion protein deposits in brain tissue. Case report: A 60-yearold female with no relevant medical developed a rapidly progressive dementia, myoclonus, pyramidal syndrome and who is currently in akinetic mutism. Until the third EEG it was possible to demonstrate the periodic complexes of biphasic sharp waves. Several tests were used to rule-out other cases of rapidly progressive dementia. Cerebral magnetic resonance imaging (MRI) showed high signal intensities over the frontal cortex bilaterally. Conclusion: This case meets the criteria for a probable diagnosis of sporadic Creutzfeldt-Jakob disease. We discuss the clinical, electroencephalographic and MRI findings.


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