2013, Number 2
Rev Cubana Hematol Inmunol Hemoter 2013; 29 (2)
Arce-Hernández AA, Villaescusa-Blanco R, Morera-Barrios LM, Junco-González Y, Merlín-Linares JC, Ramón-Rodríguez L, Hernández-Padrón C
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ABSTRACTIntroduction: multiple mieloma (MM) is a disease characterized by a monoclonal proliferation of immunoglobulins representing approximately 15 % of malignant hemopathies.
Methods: the distribution of classes, subclasses and light chains of monoclonal immunoglobulins was studied in 285 patients with MM. Three methods were used: serum protein electrophoresis for the detection of monoclonal immunoglobulins or paraproteins, immunofixation electrophoresis and double immunodiffusion to identify classes, subclasses and light chain types.
Results: 206 patients (72.28 %) with IgG MM, 73 (25,62 %) with IgA MM, and 6 (2,1 %) with IgM MM were found. The distribution of IgG subclasses was: 130 cases (63,11 %) IgG1; 43 (20,87 %) IgG2; 21 (10,19 %) IgG3: and 12 (5,83 %) IgG4. Distribution of IgA subclasses was: 59 patients (80,82 %) IgA1 and 14 (19,18 %) IgA2; 187 patients (65,62 %) showed kappa light chains and 98 (34,38 %) were lambda.
Conclusions: the data obtained in our study allowed us to identify the frequency of distribution of classes, subclasses and light chains in a sample of patients with MM.