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2013, Number 2

Rev Cubana Hematol Inmunol Hemoter 2013; 29 (2)

Treatment of children acute myeloid leukemia in Cuba

Menéndez VA, González OA, Svarch E, Rosell ME, Campo DM, Arencibia NA, Machín GS, Martínez CL, Jaime FJC, Márquez HE, Lam DRM

Language: Spanish
References: 17
Page:
PDF size: 56. Kb.


ABSTRACT

Introduction. acute myeloid leukemia represents about 20 % of all leukemias in childhood with results and survival smaller than in acute lymphoid leukemia.
Objectives: to describe the results obtained with the treatment of acute myeloid leukemia in children in some Cuban centers in from 2000 to 2008.
Methods: forty-six patients from Western provinces of Cuba including Sancti Spiritus and Villa Clara were treated. The majority of the patients were males. The median age was 9 years old. Two periods of treatment were applied, the first from 2000 to 2003 with 27 patients; and the second from 2004 to 2008 with 19 cases. The difference between the two periods was that in the second one the consolidation had short and intensive cycles.
Results: the initial remission was 71 % in the first period and 89 % in the second. Free survival was 40 % in 5 years and the overall survival (OS) was 44 %, but in the first period the OS was 30,8 % and in the second it was 63,2 %. Immunophenotype and cytogenetic and molecular alterations were studied only in 10 children. Hematopoietic transplantation was not performed sytematically.
Conclusions: these results show a level comparable to those achieved internationally, representing a major achievement of the Cuban National Health System.


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