Bello NM, Rapado VM

Language: Spanish
References: 10
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ABSTRACT

Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown aetiology characterised by inflammation and fibrosis of the biliary tree. The disease progresses to cirrhosis and liver failure and cholangiocarcinoma develops in many of patients. The mean age at diagnosis is around 40 years and men are affected more often. The disease started is usually insidious and many patients are asymptomatic at diagnosis or have many symptoms. It is often associated with inflammatory bowel disease, especially ulcerative colitis. A case of black female 53 years old patient, who began to present fatigue, abdominal discomfort, pruritus, weight loss, jaundice and choluria. She develops hepatomegaly. The diagnosis of primary sclerosing cholangitis was made by lab tests, immunological tests, retrograde endoscopic cholangiopancreatography and liver biopsy. Liver transplantation remains the only effective therapeutic option for these kinds of patients with end-stage liver disease, although high dose ursodeoxycholic acid may have a beneficial effect.

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