Isea FGA, Rodríguez RIE, Sánchez CEE, Gil AMA

Language: Spanish
References: 6
Page: 405-411
PDF size: 136.26 Kb.

ABSTRACT

Introduction: research was conducted to determine the dose-response of melon pericarp, validate its use in traditional medicine in Venezuela and promote its rational use as a medicinal plant, through scientific knowledge.
Objective: to assess the dose-response diuretic effect of the shell of the fruit of Cucumis melo var. reticulatus Ser. in rats.
Methods: fresh fruit pericarp was liquefied and placed in saline solution for 48 hours to strain it later. Oral doses of 1, 3 and 6 mL/300g were administered, compared with a respective control group, and the volume of urine produced an hour later was measured.
Results: the first dose had no diuretic effect in any case. Urinary excretion of the two higher doses differed from their respective control group. The groups treated with aqueous extract at 3 and 6 mL were different among them, as well as the control groups in those volumes. No difference was found in the diuretic action. The study found a dose-response of nonlinear regression.
Conclusions: there is a clear dose-response relationship based on urinary excretion after administration of the aqueous extract of melon shell, which supports its use as a diuretic in traditional medicine in Venezuela.

REFERENCES

1. Habib Intersimone N, Daud Thoene A, Sánchez Riera A. Efecto diurético de extractos acuosos y alcohólicos de flores de Phrygilanthus acutifolius (corpo) en ratas. Rev Cubana Plant Med [revista en la Internet]. 2005 Dic [citado 2013 Feb 13];10(3-4): Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028 - 47962005000300003&lng=es

2. Isea Fernández GA, Rodríguez Rodríguez IE, Gil Araujo MA, Sánchez Camarillo EE. Efecto diurético del extracto acuoso de pericarpio de melón (Cucumis melo L. variedad reticulatus Naud) en ratas. Rev Cubana Plant Med [revista en la Internet]. 2008 Jun [citado 2013 Feb 13];13(2): Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028- 47962008000200002&lng=es

3. Lahlou S, Tahraoui A, Israili Z, Lyoussi B. Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol. 2007;110:458-63.

4. Himanshu S, Anuj A, Ashish T, Mohan K. Evaluation of Polyherbal formulation for diuretic activity in albino rats. Asian Pacific J Trop Disease. 2012;Suppl:442-5.

5. Ratnasooriya WD, Pieris KPP, Samaratunga U, Jayakody JRAC. Diuretic activity of Spilantes acmella flowers in rats. J Ethnopharmacol. 2004;91:317-20.

6. Jadhav RB, Bhatnagar SP, Surana SJ. Diuretic activity of Squamate mistletoe, Viscum angulatum. Pharmaceutical Biol. 2010;48(4):417-21.