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2013, Number 3

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Rev Cubana Plant Med 2013; 18 (3)

Acute oral toxicity of Azadirachta indica (Neem Tree)

Berenguer RCA, Alfonso CA, Salas MH, Puente ZE, Betancourt HJ, Mora TY

Language: Spanish
References: 12
Page: 502-507
PDF size: 35.17 Kb.


ABSTRACT

Introduction: Neem tree, whose scientific name is Azadirachta indica, is a medicinal plant used by its antiseptic, antiviral, antipyretic, antimicrobial, and anti-inflammatory properties, among others. No acute toxicity studies are reported on this plant, just long-term toxicity studies.
Objectives: to evaluate the acute oral toxicity by the class method using decoction of Azadirachta indica leaves and stems orally administered to Sprague Dawley rats.
Methods: an acute oral toxicity test based on the class method was conducted. The Azadirachta indica plant decoction was administered in one dose of 2 000 mg/kg of body weight. Pathological anatomy studies were performed to analyze the toxicity in the tested substance.
Results: the evaluated substance did not show any clinical signs of toxicity or animal deaths; no alterations in the body weight of the experimental models were found. There were no alterations of diagnostic value according to the macroscopic analysis.
Conclusions: the tested decoction, orally administered at one dose, is regarded as unclassified for the animal model and the dosage used under the observed experimental conditions.


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