Serrano-Money FE, López-Alburquerque JT, Yajeya-Pérez J, Mangas-Martín A

Language: Spanish
References: 40
Page: 111-118
PDF size: 302.58 Kb.

ABSTRACT

Introduction: Post-irradiation myelopathy is a serious consequence of radiotherapy.
Objective: To chacterize the effects of low radiation doses on nerve conduction and assess the histopathological alterations in the lumbosacral region of the spinal cord of rats 4 months old.
Methods: Nineteen Wistar rats were irradiated with a single dose of 22 Gy. After irradiation the possible lesions were assessed by neurophysiological methods and at twelve months by neurophysiological and histological procedures.
Results: No denervation signs or peripheral and/or central nerve conduction abnormalities were observed. Histopathological studies detected no loss of neurons in anterior horns or long tract demyelination in the spinal cord. The possible post-irradiation damage can be monitored by atraumatic neurophysiological techniques such as somatosensory evoked potentials.
Conclusions: Low radiation doses are not harmful for the spinal cord or dorsolumbar roots.

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