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2013, Number 1

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Cir Gen 2013; 35 (1)

Role of alopurinol in peritoneal adherences when placing a polypropylene mesh. Experimental study in rats

Ayala-García MA, Ramírez-Barba ÉJ, Quiroz-Guerrero JJ,Ortiz-Martínez JJ, González-Yebra B

Language: Spanish
References: 17
Page: 16-19
PDF size: 165.04 Kb.


ABSTRACT

Objective: To determine the effect of allopurinol on peritoneal adhesions when placing a polypropylene mesh.
Setting: Experimental Surgery Unit of the University of Guanajuato, México.
Design: Experimental, prospective, comparative, controlled, double-blinded, randomized assignment study.
Statistical analysis: χ2.
Material and Methods: We compared two groups of 30 Wistar rats each, in which we placed a polypropylene mesh: Group A, without treatment, versus group B with allopurinol at mg/kg per day administered through an orogastric catheter.
Results: This study determined that the prevalence of visceral peritoneal-prosthetic adhesions in Wistar rats when placing a polypropylene mesh is of 100% with and without allopurinol treatment.
Conclusions: We did not obtain statistical differences of the beneficial effect of allopurinol in preventing adhesions, this can indicate that allopurinol’s effect is only exerted in preventing adhesions when they are due to ischemia but not when they are caused by a granulomatous-type foreign body reaction.


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