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Anales de Otorrinolaringología Mexicana

2013, Number 4

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Otorrinolaringología 2013; 58 (4)

Typing of Human Papillomavirus in Lesions of Respiratory Epithelium

Herrera MEY, Aguilar SJA, Torres PKJ, Madrid MV

Language: Spanish
References: 20
Page: 207-211
PDF size: 321.17 Kb.


ABSTRACT

Background Respiratory papillomatosis is generally believed to be caused by certain subtypes of the human papillomavirus (HPV), which causes significant morbidity in the respiratory system, block the airway; it’s recurrent and tends to become malignant.
Objective To identify serotypes of VPH in Hospital Juarez de Mexico.
Material and method An observational study that included all patients who underwent resection of upper respiratory tumors identified as papilloma between September 2009 to June 2011. Samples were shipped for analized by PCR.
Results Fifteen samples were obtained by surgical resection, 11 samples of laryngeal lesions and 4 of nasal lesions. Of the 11 patients with laryngeal tumor study, we confirmed the diagnosis of laryngeal papillomatosis in 10, 90.9%, 5 patients positive for HPV 6, 50% and 5 HPV 11 positive patients; 4 patients with nasal inverted papilloma, all patients were men. We found in all of them VPH 6 and only one co-infection VPH 11.
Conclusion Serotypes found in this study, HPV 6 and 11, are consistent with the literature. It could be useful to detect those patients whose viral serology is more prone to malignancy, and disease courses depending on the serotype, and knowing the epidemiology of our population could help us in the near future protocols about adjuvant therapies and vaccination.


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