Horcasitas PRA

Language: Spanish
References: 8
Page: 217-220
PDF size: 435.77 Kb.

ABSTRACT

Background Recurrent respiratory papilomatosis is the most common benign neoplasm of the larynx, the standard treatment for this disease consists of repeated microsuspension direct laryngoscopy cold steel resection or CO₂ laser ablaction of papillomatous growths under general anesthesia.
Objective To communicate the results in five patients with Recurrent respiratory papilomatosis treated with intralesional cidofovir.
Material and method A prospective and observational case series study was done in a secondary care children’s hospital with eight patients with severe recurrent respiratory papillomatosis, all of the patients requiring at least a debulking procedure to mantain airway patiency every two months, five patients have been treated with the injection protocol every three weeks for a total of five injections in each patient. The overall follow up was of six months or more after the last cidofovir injection.
Results It was observed marked improvement in the five patients, none of the patients have needed another debulking procedure, airway patency is normal and the voice in seven of the eight patients had a sustained improvement.
Conclusions Cidofovir is a useful drug in the treatment of laryngeal papillomatosis, but not all patients respond to treatment.

REFERENCES

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