2013, Number 4
Nasopharyngeal ventilation versus nasal continuous positive airway pressure as rescue ventilatory method. Preliminary report
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ABSTRACTIntroduction: Chorioamnionitis is common during pregnancy and associated with several perinatal complications, including postpartum infection and sepsis. Among the most frequent neonatal complications associated to chorioamnionitis are: preterm delivery, neonatal sepsis, chronic lung disease, brain injury secondary to infection, and other neurodevelopmental disorders. It is necessary to know what the risk is of early-onset neonatal sepsis in newborns to mothers with chorioamnionitis. Objective: Determine whether maternal chorioamnionitis has an association with early-onset neonatal sepsis. Methods: We performed a case-control study, in which we included 148 patients divided in two groups: group I, cases (n = 74) and group II, controls (n = 74). The sample size was calculated through difference of proportions. Results: The group of mothers with chorioamnionitis had less prenatal care, and their newborns had a larger number of infections and respiratory problems despite the indication of prophylactic antibiotic schemes. Conclusions: Newborn infants to mother with chorioamnionitis have an increased risk of early neonatal sepsis, despite the use of prophylactic antibiotics.
Tita AT, Andrews WW. Diagnosis and management of clinical chorioamnioitis. Clin Perinatol. 2010; 37: 339-54.
Reily SD, Faye OM. Chorioamnionitis and funisitis. Their implications for the neonate. Neo Reviews. 2008; 9: 411-7.
Coto GD, Ibáñez FA. Protocolo diagnóstico-terapéutico de la sepsis neonatal. Bol Pediatr. 2006; 46: 125-34.
Wynn JL, Wong HR. Pathophysiology and treatment of septic shock in neonates. Clin Perinatol. 2010; 37: 439-79.
Goldstein B, Giroir B, Randolph A. International Pediatric Sepsis Consensus Conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005; 6: 2-8.
Petrova A, Demissie K, Rhoads GG, Smulian JC, Marcella S, Ananth CV. Association of maternal fever during labor with neonatal and infant morbidity and mortality. Obstet Gynecol. 2001; 98: 20-7.
Haque KN. Neonatal sepsis in the very low birth weight preterm infants: part 1: review of pathophysiology. J Med Sci. 2010; 3: 1-10.
Haque KN. Neonatal sepsis in the very low birth weight preterm infants: part 2: review of definition, diagnosis and management. J Med Sci. 2010; 3: 11-27.
Hidalgo EA, Espino SS. Factores de riesgo obstétricos asociados a sepsis neonatal. Perinatol Reprod Hum. 2011; 25: 135-8.
Edwards RK. Chorioamnionitis and labor. Obstet Gynecol Clin N Am. 2005; 32: 287-96.
Thomas W, Speer CP. Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome? Neonatology. 2011; 99: 177-87.
Gantert M, Been JV, Gavilanes AW, Garnier Y, Zimmermann LJ, Kramer BW. Chorioamnionitis: a multiorgan disease of the fetus? J Perinatol. 2010; 30: S21-30.
Escobar GJ, Li D, Armstrong MA, Gardner MN, Flock BF, Verdi JE et al. Neonatal sepsis workups in infants ≥ 2,000 grams at birth: a population-based study. Pediatrics. 2000; 106: 256-63.
Goldenberg RL, Culhane JF, Johnson DC. Maternal infection and adverse fetal and neonatal outcomes. Clin Perinatol. 2005; 32: 523-59.
Shah GS, Budhathoki S, Das BK, Mandal RN. Risk factors in early neonatal sepsis. Kathmandu Univ Med J (KUMJ). 2006; 4: 187-91.
Popowski T, Goffinet F, Maillard F, Schmitz T, Leroy S, Kayem G. Maternal markers for detecting early-onset neonatal infection and chorioamnionitis in cases of premature rupture of membranes at or after 34 weeks of gestation: a two-center prospective study. BMC Pregnacy Childbirth. 2011; 1: 1-9.