Hernández-Gómez M, Meléndez-Hernández R, Rojas-Saiz WH, Maya-Goldsmit D, Mayén-Molina DG

Language: Spanish
References: 10
Page: 733-737
PDF size: 594.99 Kb.

ABSTRACT

Miscarriage is the loss of pregnancy before 20 weeks of gestation and occurs in 15% of clinically recognized pregnancies. However, 5% of couples present recurrent abortion, which means more than two losses whether consecutive or not. One of the main causes of both, spontaneous and recurrent abortion, are genetic. Within it, chromosomal abnormalities are the most important. So far, the only risk factor that has been clearly defined is maternal age. Nevertheless, in patients with recurrent abortion, there has been research on some other factors that generate a greater predisposition to aneuploidy, and consequently, recurrent abortion risk. One of the mechanisms that may be the link between aneuploidy risk and maternal age is the level of Follicle Stimulating Hormone (FSH). This is due to the fact that elevated levels of Follicle Stimulating Hormone have been found to modify the morphology of meiotic spindles, which in turn leads to a higher risk of aneuploidy. In this article we present a literature review on the subject, as well as the case of a patient with two abortions, one of them with trisomy 13, and the other with trisomy 18.

REFERENCES

1. Lathi Rutn B, Gray Hazard F, Heerema-McKenner A, Taylor J, Tsung Chueh J. First Trimester Miscarriage Evaluation. Seminars in Reproductive Medicine 2011;29:463- 469.

2. Alonso López A, Bermejo Huerta S, Hernández Galván R, Ayala Posadas R, González del Ángel A, Grether González P. Diagnóstico citogenético en aborto espontáneo del primer trimestre. Ginecol Obstet Mex 2011;79:779-784.

3. Robinson WP, McFadden DE, Stephenson MD. The origin of abnormalities in recurrent Aneuploidy/Polyploidy. Am J Genet 2001;69:1245-1254.

4. Rai Raj, Regan L. Recurrent Miscarriage. Lancet 2006;368:601-611.

5. Van den Berg M, Van Maarle M, van Wely M, Goddijn M. Genetics of early miscarriage. Biochim Biophys Acta 2012;1822:1951-1959.

6. Cohen R, Check JH. Recurrent Aneuploidy-Fact or fiction. Clin Exp Obstet Gynecol 2009;37:175-177.

7. Sullivan AE, Silver RM, LaCoursiere Y, Porter TF, Branch DW. Recurrent Fetal Aneuploidy and Recurrent Miscarriage. Obstet Gynecol 2004;104:784-788.

8. Nicolaides K, Falcón O. La ecografía de las 11-13+6 semanas. Fetal Medicine Foundation, Londres 2004;17-19.

9. Goddjin M, Leschot NJ. Genetic aspects of miscarriage. Bailliere´s Best Pract Res Clin Obstet Gynaecol 2000;14:855-865.

10. Vialard F, Boitrelle F, Molina-Gomes D, Selva J. Predisposition to aneuploidy in Oocyte. Cytogenet Genome Res 2011;133:127-135.