2013, Number 6
<< Back Next >>
Rev ADM 2013; 70 (6)
Nicotine and periodontal disease
Antúnez TJM, Gutiérrez JN, Flores GGS, Cárdenas FC, Treviño AMG, Martínez MHR, Rivera SG
Language: Spanish
References: 24
Page: 292-297
PDF size: 392.51 Kb.
ABSTRACT
Nicotine is a substance that directly damages the periodontium at both a cellular and molecular level, thus furthering the advance of periodontal disease. It can cause different degrees of damage and affects all periodontal tissues, such as periodontal ligament, alveolar bone, dental cement, and the gums, as well as the vascular components of all these structures. Its effect will depend on the amount inhaled and the frequency with which this occurs. The indiscriminate use of nicotine is harmful to systemic and periodontal health, irrespective of cigarette smoking (its main source, though nicotine can, for example, also be used as an insecticide). The quest to find a new substance to counteract the side effects of this alkaloid and repair the molecular and cellular damage it causes is important for the early prevention of periodontal disease.
REFERENCES
Obeid P, Bercy P. Effects of smoking on periodontal health: a review. Adv Ther. 2000; 17 (5): 230-237.
Chomyszyn-Gajewska M, Darczuk D, Galecka-Wanatowicz D, Cabala A. Influence of smoking on incidence and progression of periodontal disease. Review of the literature. Przegl Lek. 2008; 65 (5): 249-251.
Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000. 2007; 44: 178-194.
Filoche S, Cornford E, Gaudie W, Wong M, Heasman P, Thomson W. Smoking, chronic periodontitis and smoking cessation support: Reviewing the role of dental professionals. New Zealand Dent J. 2010; 106 (2): 74-77.
Malhotra R, Kapoor A, Grover V, Kaushai S. Nicotine and periodontal tissues. J Indian Soc Periodontol. 2010; 14 (1): 72-79.
Nakayama Y, Mezawa M, Araki S, Sasaki Y, Wang S, Han J, et al. Nicotine suppresses bone sialoprotein gene expression. J Periodont. 2009; 44 (5): 657-663.
Benatti B, César-Neto J, Gonçalves P, Sallum E, Nociti Jr. F. Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat. Eur J Oral Sci. 2005; 113 (5): 400-403.
Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol. 1992; 63: 322-331.
Giannopoulou C, Roehrich N, Mombelli A. Effect of nicotine-treated epithelial cells on the proliferation and collagen production gingival fibroblast. J Clin Periodontol. 2001; 28 (8): 769-775.
Chang YC, Hsieh YS, Li CK, Huang FM, Tai KW, Chou MY. Induction of c-fos expression by nicotine in human periodontal ligament fibroblast is related to celular thiol levels. J Periodontal Res. 2003; 38 (1): 44-50.
Zhou J, Olson B, Windsor L. Nicotine increases the collagen-degrading ability of human gingival fibroblasts. J Periodont Res. 2007; 42 (3): 228-235.
Koshi R, Sugano N, Orii H, Fukuda T, Ito K. Microarray analysis of nicotine-induced changes in gene expression in a macrophage-like human cell line. J Periodont Res. 2007; 42 (6): 518-526.
Lai Y, Leone CW. The relation between smoking and periodontal disease. J Mass Dent Soc. 1997; 46 (3): 17-18.
Martinez A, Silverio K, Fogo J, Kirkwood K, Rossa J. Root surface conditioning with nicotine or cotinine reduces viability and density of fibroblasts in vitro. Clin Oral Invest. 2005; 9 (3): 180-186.
Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res. 2012; 91 (2): 142-149.
Liu Y, Wu L, Wang J, Wen L, Wang X. Micro-computerized tomography analysis of alveolar bone loss in ligature- and nicotine- induced experimental periodontitis in rats. J Periodontal Res. 2010; 45 (6): 714-719.
Ma L, Zwahlen RA, Zheng LW, Sham MH. Influence of nicotine on the biological activity of rabbit osteoblasts. Clin Oral Implants Res. 2011; 22 (3): 338-342.
Nakamura T, Ono K, Honda E, Yokota M, Inenaga K. Central nicotinic stimulation reduces vascular conductance in the gingiva in anesthetized rats. J Periodont Res. 2005; 40 (1): 67-72.
Renò F, Rocchetti V, Migliario M, Cannas M. Nicotine modulates gelatinase B (MMP-9) and epilysin (MMP-28) expression in reconstituted human oral epithelium. J Oral Pathol & Med. 2011; 40 (1): 33-36.
Johnson G, Guthmiller J, Joly S, Organ C, Dawson D. Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures. J Periodontal Res. 2010; 45 (4): 583-588.
Yiyu F, Svoboda K. Nicotine inhibits human gingival fibroblast migration via modulation of Rac signaling pathways. J Clin Periodontol. 2005; 32 (12): 1200-1207.
Yanagita M, Kojima Y, Kawahara T, Kajikawa T, Oohara H, Takedachi M, et al. Suppressive effects of nicotine on the cytodifferentiation of murine periodontal ligament cells. Oral Dis. 2010; 16 (8): 812-817.
Chang YC, Lai CC, Lin LF, Ni WF, Tsai CH. The up-regulation of heme oxygenase-1 expression in human gingival fibroblasts stimulated with nicotine. J Periodontal Res. 2005; 40 (3): 252-257.
Pi SH, Jeong GS, Oh HW, Kim YS, Pae HO, Chung HT et al. Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells. J Periodontal Res. 2010; 45 (2): 177-183.