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2013, Number 3

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Gaceta Médica Espirituana 2013; 15 (3)

Epithelial thymoma as a cause of thoracic pain during an atypical exacerbation of bronchial asthma: a case report

Gómez LK, Orellana MGA, Lorenzo RJL, Concepción LA
Full text How to cite this article

Language: Spanish
References: 7
Page: 300-305
PDF size: 234.87 Kb.


Key words:

thymoma, thymic neoplasms, mediastinal tumors, bronchial asthma.

ABSTRACT

Background: the evaluation of a patient with bronchial asthma exacerbation includes the search for diseases which can simulate, complicate or perpetuate that situation. The retrosternal pain is an atypical symptom in patients with asthmatic exacerbation and among the causes that can originate this symptom are mediastinal masses like thymoma. A third part of patients with thymomas might have symptoms associated with autoimmune diseases and paraneoplastic syndromes; however, although asthma has an important immunologic component in its pathophysiology, association of thymoma with asthma is poorly documented.
Objective: to offer a clinical lesson through a presentation of a case with unusual association of thymoma and asthma.
Case presentation: a 50 year-old female patient with asthmatic exacerbation and retrosternal thoracic pain came to emergency services. A mass in anterosuperior mediastinum was observed in computed tomographic high-resolution scan and after performing surgical exeresis and immune histochemistry studies an epithelial timoma type IIB was diagnosed.
Conclusions: the presence of unusual symptoms in a patient with asthma exacerbation led to an epithelial thymoma, even when there has not been shown association between these two diseases.


REFERENCES

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  2. Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlström J, Kronenberg M, et al. CD4+ Invariant T-Cell–Receptor+ Natural Killer T Cells in Bronchial Asthma. N Engl J Med. 2006 [consultado 05-03-2013];354:1117-29. Available from :http://www.nejm.org/doi/pdf/10.1056/NEJMoa053614

  3. Hoshino M, Nakagawa T, Sano Y, Hirai K. Effect of inhaled corticosteroid on an immunoreactive thymus and activation-regulated chemokine expression in the bronchial biopsies from asthmatics. En: The Cochrane Library. 2005 Mar [consultado 05-03-2013];60(3):317-22. Available from : http://cochrane.bvsalud.org/cochrane/main.php?lang=es&lib=COC

  4. GINA 2012. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention Update 2012 [consultado 05-03-2013]. Available from : http://www.ginasthma.org/local/uploads/files/GINA_Report_March13.pdf

  5. González R, Santolaya R, Jadue A, Prats R, Mordojovich G, Rodríguez P. Neoplasias epiteliales del timo: timoma y carcinoma tímico. Caracterización, tratamiento y variables asociadas a supervivencia. Rev Chil Cir [revista electrónica]. 2012;64(6) [consultado 23-01-2013]: Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-40262012000600007&lng=en&nrm=iso

  6. eHealthMe.com: Healthcare big data for ordinary people; c2013. Asthma and Chest pain: a study of 2,835 patients [citado 27 May 2013]. Available from : http://www.ehealthme.com/cs/asthma/chest+pain

  7. Lo Nigro C, Geraci G, Sciuto A, Li Volsi F, Cupido F, Modica G. Surgical treatment of thymoma. Personal experience. G Chir [revista electrónica]. 2012;33(10) [consultado 30-04-2013]: Available from :http://www.giornalechirurgia.it/common/php/portiere.php?ID=1309dfac80cf3961bbd7dafb920c2d79




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