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Instituto Nacional de Neurología y Neurocirugía

2013, Number 2

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Arch Neurocien 2013; 18 (2)

Incidence and determinants of dyskinesias and motor fluctuations in a retrospective multicenter cohort of Mexican patients with Parkinson’s disease

Cervantes-Arriaga A, Rodríguez-Violante M, Zuñiga-Ramírez C, Estrada-Bellmann I, López-Ruiz M, Cantú-Brito C, Martínez-Ramírez D, Morales-Briceño H, Carlos-Ramírez, Rosalva-Mathieu

Language: Spanish
References: 10
Page: 78-81
PDF size: 75.43 Kb.


ABSTRACT

Dyskinesia and motor fluctuations are the main complications and limitations of dopamine replacement therapy. Objective: to determine the prevalence and incidence of motor complications in multicentric and retrospective cohort of Mexican patients with Parkinson’s disease. Material and methods: we included 884 patients with PD treated at three referral centers in Mexico City, a center in Guadalajara and a center in Monterrey during the period between January and December 2011. Results: The incidence of dyskinesias in person-time was 42 cases per 1000 person-years. The incidence rate of fluctuations in person-time was 53 cases per 1000 person-years. Conclusions: the prevalence and incidence of motor fluctuations and diskynesias is less than expected which warrants further study. This is the first EP multicenter study with a sample size of this magnitude made in our country.


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