2014, Number 1
Thrombophilic Factors in Women with Repeated Abortions and with Deep Vein Thrombosis in the Puerperium
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ABSTRACTBackground: Thrombofilic factors in women are cause of morbidity and mortality during pregnancy and puerperium.
Objective: To study the relationship of thrombophilic factors with recurrent miscarriages and deep venous thrombosis at the puerperium.
Material and method: A retrospective case-control study was done with the database of Clinic Laboratory and Hematology Service at 25 de Mayo Clinic and the Regional Center of Hemotherapy at Mar del Plata city, Argentina. Cases group included women with recurrent miscarriages and deep venous thrombosis at puerperium attending at 25 de Mayo Clinic during the period 2007-2009. Control group included women who were regular blood donors without history of recurrent miscarriages or deep venous thrombosis at the same period in the Regional Center of Hemotherapy of the city and pared by the same age. The main measure was the existence or not of thrombophilic factors.
Results: The lupic inhibitor was the acquired thrombophilic factor with greater statistical significance (p=0.0001), followed by hyperhomocysteinemia in all groups. In early abortions, there was no statistically significant difference with genetic mutations; instead, in late-term abortions only found such a difference with gene G20210A prothrombin and 5-10 MTHFR. In women with postpartum deep venous thrombosis mutations at gene prothrombin G20210A had the highest statistical significance; followed by IL, RPCa, HHcy and factor V de Leiden gene mutation.
Conclusions: The lupic inhibitor was the most related with recurrent miscarriages and post-partum deep venous thrombosis. We found no relationship between recurrent miscarriages and factor V Leiden, but we found relation with gen prothrombin G20210A only in late-term abortions and venous thrombosis at puerperium postpartum.
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