Martínez AJ, Weisser MT

Language: Spanish
References: 27
Page: 397-407
PDF size: 57.36 Kb.

ABSTRACT

Ozone is an element of great oxidative power that has shon its therapeutic properties, but it is potentially toxic. To identify the parameters to guarantee safety during the treatment with ozone in the dental clinic. A research study was performed in two phases: firstly, literature review of 38 scientific publications in Hinari, Cochrane, Pubmed, Scopus, Scielo, Dynamed, EBSCOH databases through Infomed net(2005-2012) in which 27 papers were selected. Secondly, theoretical methods of analysis and synthesis as well as induction and deduction were applied, taking into account the accumulated experience by authors after more than 15 years of using ozone therapy in dental clinic, in order to find out the necessary criteria on safety of subjects. For the purpose of guaranteeing safety in ozone therapy for dental use, it is necessary to have informed consent of patient, to observe weather conditions to schedule consultation at the most suitable time, to avail of an ozone concentration equipment, to keep saliva ejector or other disposal method, to comply with the ozone equipment standards set by the manufacturer, to stop giving treatment if there is any adverse reaction to ozone and to register any event in the medical history, and to develop controlled clinical and randomized assay protocols on this topic and to publish the final results. Ozone is safe provided that it is used according to the established norms and appropriate therapeutic dose. Some parameters were identified to keep in mind for the ozone therapy in dental clinic. More clinical assays are required to justify the role of the dental ozone therapy, through evidence-based odontology.

REFERENCES

1. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. J Dent. 2008;36:10416.

2. Lynch E. Ozone: The Revolution in Dentistry. Chicago: Quintessence Publishing; 2004. ISBN 1850970882.

3. Bocci V. Ozone as a bioregulator. Pharmacology and toxicology of ozone therapy today. J Biol Regul Homeost Agents. 1996;10:31-53.

4. Sagai M, Bocci V. Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? Medical Gas Research [Internet]. 2011;[Citado: 2012 Ago 7];1(1)[aprox. 1 p.]. Disponible en: http://dx.doi.org/10.1186/2045-9912-1-29

5. ISPUB - Ozone: A new face of dentistry. Journal of dental science [Internet]. 2011 [Citado: 2012 Ago 7];7(2)[aprox. 1 p.]. Disponible en: http://www.ispub.com/journal/the_internet_journal_of_dental_science /volume_7_number_2_20/article/ozone-a-new-face-of-dentistry.html

6. Saini R. Ozone therapy in dentistry: A strategic review. Journal of natural science, biology, and medicine [Internet]. 2011[Citado: 2012 Ago 7];2(2)[aprox. 2 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt= Abstract&list_uids=22346227

7. Bhateja S. The miraculous healing therapy? Ozone therapy? In dentistry Indian Journal of Dentistry [Internet]. 2012 [Citado: 2012 Ago 7];2(1)[aprox. 1 p.]. Disponible en: http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=ScienceSearch& _method=citationSearch&_piikey=S0975962X12000561&_version=1&_returnURL= http%3A%2F%2Fwww.scirus.com%2Fsrsapp%2F&md5=ab04e9437726568172d30 0d7151808d2

8. Bocci V, Zanardi I, Travagli V. Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects. Medical Gas Research [Internet]. 2011 [Citado: 2012 Ago 7];1(1) [aprox. 1 p.]. Disponible en: http://dx.doi.org/10.1186/2045-9912-1-6

9. Loncar B, Stipetic MM, Matosevic D, Tarle Z. Ozone Application in Dentistry Archives of Medical Research [Internet]. 2009[Citado: 2012 Ago 7];40(2)[aprox. 1 p.]. Disponible en: http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=ScienceSearch& _method=citationSearch&_piikey=S0188440908002907&_version=1&_returnURL= http%3A%2F%2Fwww.scirus.com%2Fsrsapp%2F&md5=260ab28f08254052abeb63 3d64ca7601

10. Estrela C, Estrela CRA, Decurcio DA, Hollanda ACB, Silva JA. Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infectedhuman root canals. Int Endodont J [Internet]. 2007;[Citado: 2012 Ago 7]; 40:8593

11. Menéndez S. Eficacia y seguridad del Oleozón® tópico en el tratamiento de pacientes con impétigo. Rev Panamericana de Infectologia. 2007;9(2).

12. Bocci V. Ozone as Janus: This controversial gas can be either toxic or medically useful. Mediators of Inflammation [Internet]. 2004 [Citado: 2012 Ago 7];13(1) [aprox. 1 p.]. Disponible en: http://dx.doi.org/10.1080/0962935062000197083

13. Bocci VA. Tropospheric Ozone Toxicity vs. Usefulness of Ozone Therapy Archives of Medical Research [Internet]. 2007 [Citado: 2012 Ag 7];38(2)[aprox. 2 p.]. Disponible en: http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=ScienceSearch& _method=citationSearch&_piikey=S0188440906003390&_version=1&_returnURL= http%3A%2F%2Fwww.scirus.com%2Fsrsapp%2F&md5=2a339bc60bfb9b6bfa5a8b 65c3ab4398

14. Bocci V. Is it true that ozone is always toxic? The end of a dogma 2006 Toxicology and Applied Pharmacology [Internet]. 2011[Citado: 2012 Ago 7];216(3) [aprox. 9 p.]. Disponible en: http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=ScienceSearch& _method=citationSearch&_piikey=S0041008X06002195&_version=1&_returnURL= http%3A%2F%2Fwww.scirus.com%2Fsrsapp%2F&md5=889929fd8b7b606f3cb3a7 1466ec9302

15. Programa Nacional de Medicina Natural y Tradicional. La Habana: Editorial Ciencias Médicas; 2008.

16. Gupta G, Mansi B. Ozone therapy in periodontics. Journal of medicine and life [Internet] 2012; [Citado: 2012 Ago 7];5(1)[aprox. 8 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt= Abstract&list_uids=22574088 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3307081

17. Valacchi G, Bocci V. Studies on the biological effects of ozone: Release of factors from human endothelial cells. Mediat Inflamm. 2010; 9:271-6.

18. Eick S, Tigan M, Sculean A. Effect of ozone on periodontopathogenic speciesan in vitro study. Clinical Oral Investigations. 2011;10.

19. Johansson E, Claesson R, van Dijken JW. Antibacterial effect of ozone on cariogenic bacterial species. J Dent 2009;37:449-53.

20. Burgassi S, Zanardi I, Travagli V, Montomoli E, Bocci V. How much ozone bactericidal activity is compromised by plasma components? J Appl Microbiol. 2009;106:171521.

21. Sharma M, Hudson JB. Ozone gas is an effective and practical antibacterial agent. Am J Infect Control. 2008;36:55963.

22. Yamada K, Yama M, Takaku Y, Kakizawa T, Kimizuka R, Okuda K, et al. Antimicrobial activity of super-oxidised water against oral microorganisms. Arch Oral Biol 2010;55:397400.

23. Huth KC, Quirling M, Maier S, Kamereck K, Alkhayer M, Paschos E, et al. Effectiveness of ozone against endodontopathogenic microorganisms in a root canal biofilm model. Int Endod J. 2009;42:313.

24. Mayor Hernández F, Martínez Abreu J, Moure Ibarra MD, García Valdés MR. Aplicación del Oleozón® en el tratamiento de las pericoronaritis. Rev Méd Electrón [Internet]. 2011 [Citado: 2012 Ago 7];33(1) [aprox. 1 p.]. Disponible en: http://www.revmatanzas.sld.cu/revista%20medica/ano%202011/vol1%202011/te ma11.htm

25. Martínez Abreu J, Chapelín Arencibia Y, Peña Ruiz T. OLEOZÓN® en el tratamiento de la gingivitis crónica edematosa. Rev Méd electrón [Internet]. 2006 [Citado: 2012 Ago 7];28(6) [aprox. 1 p.]. Disponible en: http://www.cpimtz.sld.cu/revista%20medica/ano%202006/vol6%202006/tema05.htm

26. Martínez Abreu J, Peña Ruiz T, Llanes llanes E, Ilzarbe LM. Papel de los metabolitos reactivos del oxígeno en los periodontopatías. Rev Méd Electrón [Internet]. 2007 [Citado: 2012 Ago 7];29(5)[aprox. 1 p.]. Disponible en: http://www.cpimtz.sld.cu/revista%20medica/ano%202007 /vol5%202007/ tema15.htm

27. Martínez Abreu J. Oleozón® en el tratamiento del absceso periodontal agudo en pacientes diabéticos. (N. del T.: En español: [tesis]). Matanzas: Universidad de Ciencias Médicas de Matanzas; 2009.