Aviña FJA, Hernández ADA

Language: Spanish
References: 18
Page: 79-83
PDF size: 183.20 Kb.

ABSTRACT

The enlargement in the population with diabetes mellitus had increased in the incidence of the newborn from diabetic mothers with malformations by diabetic embryopathy caused by inadequate metabolic control of the disease during the first trimester of pregnancy, especially after the third week of pregnancy and before the seventh during embryogenesis and organogenesis. The clinical manifestations show slight appearance of facial dysmorphism, and moderated skeletal muscle malformations mainly in lower segments (caudal dysgenesis) with vertebral abnormalities, hypoplasia of lower limbs and polydactyly with supernumerary toe in hallucal location. Some others defects may also occur in heart and great vessels, abnormalities in the development of the brain and neural tube and less frequently gastrointestinal, genital or urinary diseases. Newborn of diabetic mothers should be carefully reviewed to detect early these defects and try to work on those that are modifiable, although the main objective should be obtain adequate glycemic level during pregnancy and raise the awareness about these risks.

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