2014, Number 2
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Salud Mental 2014; 37 (2)
El polimorfismo 5-HTTLPR y el intento suicida en adolescentes deprimidos
Sarmiento HEI, Ulloa FRE, Brenes PME, Camarena MB, Aguilar GA, Hernández MS
Language: Spanish
References: 31
Page: 97-101
PDF size: 254.30 Kb.
ABSTRACT
Suicide is a common cause of death in adolescents, being mainly
associated with depression. In addition, the “SS” genotype and the
“S” allele of 5-HTTLPR polymorphism of SLC6A4 gene of serotonin
transporter have been associated with suicidal behavior. The aims of
the present study were to compare the frequency of the polymorphism
of SLC6A4 gene in depressed adolescents with and without history of
suicidal attempt and to determine if the “SS” genotype was associated
with specific clinical features.
Method:
The study examined 53 adolescents who were evaluated with the Diagnostic
Interview Schedule for Affective Disorders and Schizophrenia
for school-aged children-present and lifetime version (K-SADS-PL). A
DNA sample was obtained and 5HTTLPR polymorphisms of SLC6A4
gene were analyzed.
Results:
There were no differences in the frequency of genotype and allele frequencies
between groups. However, patients with the “SS” genotype
reported a higher frequency of hopelessness and a greater number of
suicide attempts.
Conclusions:
The frequency of “SS” genotype did not differ between patients with
and without suicidal behavior, but patients with this genotype exhibited
differences in clinical features of depression which need further
study.
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