Gutiérrez-Casillas S, Flores-Rivera OI, Alonso-Martínez D, Macías RF, Espino-López E

Language: Spanish
References: 4
Page: 335-338
PDF size: 550.99 Kb.

ABSTRACT

Histoplasmosis is the most common endemic mycosis causing human infection. Is a dimorphic fungus in the environment and a yeast in tissues at 37ºC, particularly in endemic areas. The organism grows in soil rich in bird droppings. The initial exposure to Histoplasma capsulatum is through the airways, but once inhaled into the alveoli, the organism spreads easily in macrophages through the reticuloendothelial system. The main presentation is pulmonary. Its diagnosis can be made by culture Sabouraud agar, DNA specific for H. capsulatum, histopathology, polysaccharide antigen detection circulation H. capsulatum by an enzyme immunoassay (EIA) in the urine, serum and other body fluids. The treatment of choice is itraconazole and amphotericin B in severe cases.

REFERENCES

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2. Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007;45:807-825.

3. Lindsley MD, Holland HL, Bragg SL, et al. Production and evaluation of reagents for detection of Histoplasma capsulatum antigenuria by enzyme immunoassay. Clin Vaccine Immunol 2007;14:700-709.

4. Scheel CM, Samayoa B, Herrera A, et al. Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients. Clin Vaccine Immunol 2009;16:852-858.